FGF10

FGF10
بنى متوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معرفات بنك بيانات البروتين
	1NUN
معرفات
أسماء بديلة	FGF10, fibroblast growth factor 10
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 602115 MGI: MGI:1099809 HomoloGene: 3284 GeneCards: 2255
علم الوجود الجيني
وظائف جزيئية	• heparin binding; • type 2 fibroblast growth factor receptor binding; • growth factor activity; • ‏GO:0001948، ‏GO:0016582 ربط بروتيني; • fibroblast growth factor receptor binding; • chemoattractant activity; • protein tyrosine kinase activity; • 1-phosphatidylinositol-3-kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
مكونات خلوية	• الفراغ خارج الخلية; • نواة; • cell surface; • ‏GO:0005578 نسيج بيني خارج الخلية; • غشاء خلوي; • خارج خلوي; • collagen-containing extracellular matrix;
عمليات حيوية	• bud outgrowth involved in lung branching; • limb bud formation; • organ growth; • semicircular canal morphogenesis; • embryonic pattern specification; • bud elongation involved in lung branching; • positive regulation of canonical Wnt signaling pathway; • muscle cell fate commitment; • إفراز الدموع; • positive regulation of Ras protein signal transduction; • positive regulation of urothelial cell proliferation; • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; • limb development; • radial glial cell differentiation; • female genitalia morphogenesis; • mesonephros development; • odontogenesis of dentin-containing tooth; • prostatic bud formation; • إعادة نمذجة الوعاء الدموي; • regulation of saliva secretion; • توليد الأوعية; • establishment of mitotic spindle orientation; • positive regulation of ERK1 and ERK2 cascade; • embryonic digestive tract morphogenesis; • تشكل العضو الحيواني; • hair follicle morphogenesis; • metanephros development; • lung saccule development; • lung epithelium development; • positive regulation of Notch signaling pathway; • negative regulation of cell population proliferation; • branch elongation involved in salivary gland morphogenesis; • branching involved in salivary gland morphogenesis; • positive regulation of white fat cell proliferation; • bronchiole morphogenesis; • limb morphogenesis; • blood vessel morphogenesis; • lung development; • نمو الغدة الزعترية; • positive regulation of fibroblast proliferation; • negative regulation of cell differentiation; • ERK1 and ERK2 cascade; • positive regulation of epithelial cell migration; • positive regulation of mitotic cell cycle; • spleen development; • smooth muscle cell differentiation; • ‏GO:0060469، ‏GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of Wnt signaling pathway; • Harderian gland development; • protein localization to cell surface; • respiratory system development; • epidermis development; • positive regulation of peptidyl-tyrosine phosphorylation; • metanephros morphogenesis; • pancreas development; • mammary gland bud formation; • positive chemotaxis; • mesenchymal-epithelial cell signaling involved in lung development; • positive regulation of hair follicle cell proliferation; • lacrimal gland development; • positive regulation of MAPK cascade; • تمايز خلوي; • positive regulation of keratinocyte proliferation; • positive regulation of ATP-dependent activity; • positive regulation of epithelial cell proliferation involved in wound healing; • epithelial cell differentiation; • organ induction; • positive regulation of epithelial cell proliferation; • epidermis morphogenesis; • التئام الجروح; • epithelial cell proliferation; • regulation of activin receptor signaling pathway; • positive regulation of DNA replication; • انجذاب كيميائي; • embryonic genitalia morphogenesis; • salivary gland development; • positive regulation of keratinocyte migration; • response to lipopolysaccharide; • نمو الغدة الدرقية; • keratinocyte proliferation; • semicircular canal fusion; • mammary gland specification; • epithelial cell migration; • white fat cell differentiation; • تنظيم التعبير الجيني; • lung alveolus development; • branching morphogenesis of an epithelial tube; • embryonic digestive tract development; • lung proximal/distal axis specification; • fibroblast growth factor receptor signaling pathway involved in mammary gland specification; • actin cytoskeleton reorganization; • positive regulation of vascular endothelial growth factor receptor signaling pathway; • pituitary gland development; • response to estradiol; • secretion by lung epithelial cell involved in lung growth; • mesenchymal cell differentiation involved in lung development; • lung morphogenesis; • ‏GO:1904578 response to organic cyclic compound; • somatic stem cell population maintenance; • tissue regeneration; • otic vesicle formation; • epithelial cell proliferation involved in salivary gland morphogenesis; • cell-cell signaling; • male genitalia morphogenesis; • ‏GO:1900404 positive regulation of DNA repair; • salivary gland morphogenesis; • MAPK cascade; • embryonic camera-type eye development; • induction of positive chemotaxis; • urothelial cell proliferation; • تشكل العضو الحيواني; • fibroblast growth factor receptor signaling pathway; • regulation of smoothened signaling pathway; • determination of left/right symmetry; • inner ear morphogenesis; • ضبط زيادي للتكاثر الخلوي; • submandibular salivary gland formation; • type II pneumocyte differentiation; • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; • digestive tract development; • regulation of epithelial cell proliferation; • epithelial tube branching involved in lung morphogenesis; • positive regulation of lymphocyte proliferation; • ‏GO:0003257، ‏GO:0010735، ‏GO:1901228، ‏GO:1900622، ‏GO:1904488 ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني; • phosphatidylinositol phosphate biosynthetic process; • phosphatidylinositol-3-phosphate biosynthetic process; • peptidyl-tyrosine phosphorylation; • regulation of signaling receptor activity; • positive regulation of protein kinase B signaling; • positive regulation of G1/S transition of mitotic cell cycle;
	المصادر:Amigo / QuickGO
تماثلات متسلسلة
	O15520
	O35565
	‏NM_004465 XM_005248264، ‏NM_004465
	NM_008002
	‏XP_005248321 NP_004456، ‏XP_005248321
	NP_032028
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

FGF10‏ (Fibroblast growth factor 10) هوَ بروتين يُشَفر بواسطة جين FGF10 في الإنسان.^[1]^[2]

الوظيفة

الأهمية السريرية

المراجع

قراءة متعمقة

Igarashi M، Finch PW، Aaronson SA (مايو 1998). "Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7)". The Journal of Biological Chemistry. ج. 273 ع. 21: 13230–5. DOI:10.1074/jbc.273.21.13230. PMID:9582367.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)
Sekine K، Ohuchi H، Fujiwara M، Yamasaki M، Yoshizawa T، Sato T، Yagishita N، Matsui D، Koga Y، Itoh N، Kato S (يناير 1999). "Fgf10 is essential for limb and lung formation". Nature Genetics. ج. 21 ع. 1: 138–41. DOI:10.1038/5096. PMID:9916808.
Jimenez PA، Rampy MA (فبراير 1999). "Keratinocyte growth factor-2 accelerates wound healing in incisional wounds". The Journal of Surgical Research. ج. 81 ع. 2: 238–42. DOI:10.1006/jsre.1998.5501. PMID:9927546.
Ropiquet F، Giri D، Kwabi-Addo B، Schmidt K، Ittmann M (سبتمبر 2000). "FGF-10 is expressed at low levels in the human prostate". The Prostate. ج. 44 ع. 4: 334–8. DOI:10.1002/1097-0045(20000901)44:4<334::AID-PROS11>3.0.CO;2-G. PMID:10951499.
Marchese C، Felici A، Visco V، Lucania G، Igarashi M، Picardo M، Frati L، Torrisi MR (أبريل 2001). "Fibroblast growth factor 10 induces proliferation and differentiation of human primary cultured keratinocytes". The Journal of Investigative Dermatology. ج. 116 ع. 4: 623–8. DOI:10.1046/j.0022-202x.2001.01280.x. PMID:11286634.
Bagai S، Rubio E، Cheng JF، Sweet R، Thomas R، Fuchs E، Grady R، Mitchell M، Bassuk JA (يونيو 2002). "Fibroblast growth factor-10 is a mitogen for urothelial cells". The Journal of Biological Chemistry. ج. 277 ع. 26: 23828–37. DOI:10.1074/jbc.M201658200. PMID:11923311.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)
Yeh BK، Igarashi M، Eliseenkova AV، Plotnikov AN، Sher I، Ron D، Aaronson SA، Mohammadi M (مارس 2003). "Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors". Proceedings of the National Academy of Sciences of the United States of America. ج. 100 ع. 5: 2266–71. DOI:10.1073/pnas.0436500100. PMC:151329. PMID:12591959.
Upadhyay D، Lecuona E، Comellas A، Kamp DW، Sznajder JI (يونيو 2003). "Fibroblast growth factor-10 upregulates Na,K-ATPase via the MAPK pathway". FEBS Letters. ج. 545 ع. 2–3: 173–6. DOI:10.1016/S0014-5793(03)00527-1. PMID:12804770.
Izvolsky KI، Zhong L، Wei L، Yu Q، Nugent MA، Cardoso WV (أكتوبر 2003). "Heparan sulfates expressed in the distal lung are required for Fgf10 binding to the epithelium and for airway branching". American Journal of Physiology. Lung Cellular and Molecular Physiology. ج. 285 ع. 4: L838-46. DOI:10.1152/ajplung.00081.2003. PMID:12818887.
Tomlinson DC، Grindley JC، Thomson AA (أبريل 2004). "Regulation of Fgf10 gene expression in the prostate: identification of transforming growth factor-beta1 and promoter elements". Endocrinology. ج. 145 ع. 4: 1988–95. DOI:10.1210/en.2003-0842. PMID:14726452.
Upadhyay D، Bundesmann M، Panduri V، Correa-Meyer E، Kamp DW (يوليو 2004). "Fibroblast growth factor-10 attenuates H2O2-induced alveolar epithelial cell DNA damage: role of MAPK activation and DNA repair". American Journal of Respiratory Cell and Molecular Biology. ج. 31 ع. 1: 107–13. DOI:10.1165/rcmb.2003-0064OC. PMID:14975937.
Theodorou V، Boer M، Weigelt B، Jonkers J، van der Valk M، Hilkens J (أغسطس 2004). "Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas". Oncogene. ج. 23 ع. 36: 6047–55. DOI:10.1038/sj.onc.1207816. PMID:15208658.
Ibrahimi OA، Yeh BK، Eliseenkova AV، Zhang F، Olsen SK، Igarashi M، Aaronson SA، Linhardt RJ، Mohammadi M (يناير 2005). "Analysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerization". Molecular and Cellular Biology. ج. 25 ع. 2: 671–84. DOI:10.1128/MCB.25.2.671-684.2005. PMC:543411. PMID:15632068.
Entesarian M، Matsson H، Klar J، Bergendal B، Olson L، Arakaki R، Hayashi Y، Ohuchi H، Falahat B، Bolstad AI، Jonsson R، Wahren-Herlenius M، Dahl N (فبراير 2005). "Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands". Nature Genetics. ج. 37 ع. 2: 125–7. DOI:10.1038/ng1507. PMID:15654336.
Kovacs D، Falchi M، Cardinali G، Raffa S، Carducci M، Cota C، Amantea A، Torrisi MR، Picardo M (فبراير 2005). "Immunohistochemical analysis of keratinocyte growth factor and fibroblast growth factor 10 expression in psoriasis". Experimental Dermatology. ج. 14 ع. 2: 130–7. DOI:10.1111/j.0906-6705.2005.00261.x. PMID:15679583.
Ye F، Duvillié B، Scharfmann R (فبراير 2005). "Fibroblast growth factors 7 and 10 are expressed in the human embryonic pancreatic mesenchyme and promote the proliferation of embryonic pancreatic epithelial cells". Diabetologia. ج. 48 ع. 2: 277–81. DOI:10.1007/s00125-004-1638-6. PMID:15690149.
Beer HD، Bittner M، Niklaus G، Munding C، Max N، Goppelt A، Werner S (أغسطس 2005). "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair". Oncogene. ج. 24 ع. 34: 5269–77. DOI:10.1038/sj.onc.1208560. PMID:15806171.

[1]

[2]

Search

FGF10

محتويات

الوظيفة

الأهمية السريرية

المراجع

قراءة متعمقة