Collagen, type XXVII, alpha 1

Collagen alpha-1 (XXVII) chain (COL27A1) is a protein that in humans is encoded by the COL27A1 gene.^[5]

COL27A1
Identifiers
Aliases	COL27A1, STLS, collagen type XXVII alpha 1, collagen type XXVII alpha 1 chain
External IDs	OMIM: 608461; MGI: 2672118; HomoloGene: 69400; GeneCards: COL27A1; OMA:COL27A1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q32 Start 114,155,537 bp[1] End 114,312,511 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B3 Start 63,214,004 bp[2] End 63,334,991 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia cerebellar vermis pancreatic ductal cell canal of the cervix pylorus cartilage tissue cerebellar hemisphere renal medulla right hemisphere of cerebellum skin of arm Top expressed in molar lesser wing of sphenoid bone stria vascularis otolith organ utricle internal carotid artery hand index finger phalanx of index finger rib More reference expression data BioGPS n/a
Gene ontology Molecular function extracellular matrix structural constituent metal ion binding extracellular matrix structural constituent conferring tensile strength Cellular component extracellular region fibrillar collagen trimer collagen endoplasmic reticulum lumen extracellular space extracellular matrix collagen-containing extracellular matrix Biological process growth plate cartilage chondrocyte development extracellular matrix organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85301 373864 Ensembl ENSG00000196739 ENSMUSG00000045672 UniProt Q8IZC6 Q5QNQ9 RefSeq (mRNA) NM_032161 NM_032888 NM_025685 RefSeq (protein) NP_116277 NP_079961 Location (UCSC) Chr 9: 114.16 – 114.31 Mb Chr 4: 63.21 – 63.33 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

COL27A1 is a type XXVII collagen. It was discovered by James Pace.^[6] This gene appears to be turned on in cartilage, the eye, and in the ear. Type XXVII collagen is related to the "fibrillar" class of collagens and may play a role in development of the skeleton.

Fibrillar collagens, such as COL27A1, compose one of the most ancient families of extracellular matrix molecules. They form major structural elements in extracellular matrices of cartilage, skin, and tendon.^[5][7]