Ecto-ADP-ribosyltransferase 4 is an enzyme that in humans is encoded by the ART4 gene.[5][6] ART4 has also been designated as CD297 (cluster of differentiation 297).
| ART4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | ART4, ARTC4, CD297, DO, DOK1, ADP-ribosyltransferase 4 (Dombrock blood group), DO/ADP-ribosyltransferase 4 (inactive) (Dombrock blood group) | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 110600; MGI: 1202710; HomoloGene: 10883; GeneCards: ART4; OMA:ART4 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinositol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.[6]
Blood group antigens
Several antigens have been recognised in this family. These are DO*A, DO*JO1, DO*A-WL, DO*DOYA, DO*B, DO*B-WL, DO*B-SH-Q149K, DO*B-(WL)-I175N, DO*HY1, DO*HY2 and DO*DOMR.
References
Further reading
External links
- ART4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human ART4 genome location and ART4 gene details page in the UCSC Genome Browser.
- Human DOK1 genome location and DOK1 gene details page in the UCSC Genome Browser.
- Dombrock blood group antigen NCBI Blood Group Antigen Gene Mutation Database
This article incorporates text from the United States National Library of Medicine, which is in the public domain.