EPH receptor B1

EPHB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DJS, 2EAO, 3ZFX
Identifiers
Aliases	EPHB1, Ephb1, 9330129L11, AW488255, C130099E04Rik, Cek6, ENSMUSG00000074119, Elk, Elkh, Hek6, Net, EPHT2, EPH receptor B1, ELK, NET
External IDs	OMIM: 600600; MGI: 1096337; HomoloGene: 20936; GeneCards: EPHB1; OMA:EPHB1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	135,260,467 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	102,231,892 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; ganglionic eminence; ; Brodmann area 23; ; secondary oocyte; ; cerebellum; ; cerebellar cortex; ; ventricular zone; ; cerebellar hemisphere; ; primary visual cortex; ; right hemisphere of cerebellum;
	Top expressed in
	otic vesicle; ; lumbar subsegment of spinal cord; ; otolith organ; ; utricle; ; inferior colliculus; ; substantia nigra; ; deep cerebellar nuclei; ; superior colliculus; ; Rostral migratory stream; ; medial ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; ephrin receptor activity; axon guidance receptor activity; transmembrane-ephrin receptor activity; protein-containing complex binding;
Cellular component	integral component of membrane; endosome; cell projection; early endosome membrane; membrane; integral component of plasma membrane; extracellular region; dendrite; extracellular exosome; endoplasmic reticulum; cytosol; plasma membrane; axon; cytoplasm; filopodium tip; membrane raft; neuron projection; receptor complex; glutamatergic synapse;
Biological process	phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; nervous system development; dendritic spine development; cell-substrate adhesion; regulation of JNK cascade; protein phosphorylation; cell adhesion; regulation of neuron death; regulation of ERK1 and ERK2 cascade; protein autophosphorylation; peptidyl-tyrosine phosphorylation; immunological synapse formation; axon guidance; optic nerve morphogenesis; central nervous system projection neuron axonogenesis; retinal ganglion cell axon guidance; ephrin receptor signaling pathway; camera-type eye morphogenesis; positive regulation of synapse assembly; dendritic spine morphogenesis; angiogenesis; skeletal muscle satellite cell activation; cranial nerve development; neurogenesis; establishment of cell polarity; detection of temperature stimulus involved in sensory perception of pain; cell chemotaxis; neural precursor cell proliferation; negative regulation of skeletal muscle satellite cell proliferation; negative regulation of satellite cell differentiation; modulation of chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	2047
	270190
	ENSG00000154928
	ENSMUSG00000032537
	P54762
	Q8CBF3
	NM_004441
	NM_001168296; NM_173447
	NP_004432
	NP_001161768; NP_775623
	Wikidata
View/Edit Human	View/Edit Mouse

Ephrin type-B receptor 1 is a protein that in humans is encoded by the EPHB1 gene.^[5]^[6]

Function

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.^[6]

Interactions

EPH receptor B1 has been shown to interact with:

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EPH receptor B1

Contents

Function

Interactions

References

Further reading