Earlobe

The earlobe, as a body part built of epithelium and connective tissue, might appear to be derived from dermatome.^[4] But this is not the case, as in the surrounding tissue there are no somites and thus no dermatome. In this area, the dermis is derived from cells of mesenchymal cells: the mesenchyme is derived from the sclerotome and splanchnopleura located in the nearby regions of the torso.^[5]

The earlobe as a body part arises and develops in the vicinity of auricular follicle, as a result of cascade induction:^[6]

1. The first-level inductor is the central segment of Archenteron's roof, which induces the production of the Medulla oblongata (part of the Hindbrain).
2. The second-level inductor is the Medulla oblongata, which induces the production of a pair of auricular follicles derived from the mesoderm.
3. The third-level inductor is the auricular follicle, which induces the production of the auditory bulla.

Earlobes average about 2 centimeters long, and elongate slightly with age.^[7] Although the "free" vs. "attached" appearance of earlobes is often presented as an example of a simple "one gene – two alleles" Mendelian trait in humans, earlobes do not all fall neatly into either category; there is a continuous range from one extreme to the other, suggesting the influence of several genes.^[8][9][10]

Earlobes are normally smooth, but occasionally exhibit creases. Creased earlobes are sometimes associated with genetic disorders in children, including Beckwith-Wiedemann syndrome.^[24] In some early studies, earlobe creases were thought to be associated with an increased risk of heart attack and coronary heart disease. But more recent studies have concluded that, since earlobes become more creased with age, and older people are more likely to have heart disease than younger people, age rather than intrinsic factors may account for the findings linking heart attack to earlobe creases.^[24] The earlobe crease is also called Frank's Sign.

Earlobe piercing and stretching

Piercing the earlobes is a commonplace activity in many cultures in many historical eras; no other location on the body is as commonly pierced. Consequently, injury to the earlobe due to the weight of heavy earrings is also common.^[25] Some cultures practice earlobe stretching for decorative effects, using piercing ornaments to stretch and enlarge the earlobes to accommodate plugs.

Negative effects of wearing earrings

Some research has found that the most frequent complications connected with wearing earrings are:^[26]

• inflammation,
• keloids,
• loss of tissue by tearing, and
• mechanical division of earlobes.

A noticeable relationship has been found by Polish scientists between the piercing of young girls' earlobes and their subsequently developing allergic skin reactions.^[27][28][29] In the view of Professor Ewa Czarnobilska, the manager of the research team, the primary reason for the allergies connected to earrings is the presence of nickel, which is a common component of the alloys used in jewelry production and leaches from the earrings.^[28][29] The symptom seen is generally eczema, and is often misdiagnosed as a food allergy, for instance to milk. The specific mechanism in allergies caused by earrings is the contact of nickel ions with the lymphatic system.^[28][29]

The study noted that children who stopped wearing earrings did not see the disappearance of the allergic symptoms. The immune system remembers the presence of the nickel ions in the person's blood and lymph, so the child can still react to:^[28][29]

• metal parts of wardrobe,
• dental braces,
• dental prosthesis,
• orthotics,
• meals cooked in pots with addition of nickel,
• margarine (nickel is a catalyst in hydrogenation of unsaturated fats),
• coins,
• chocolate,
• nuts,
• leguminous vegetables,
• wine, and
• beer.

Research by allergists has found that in a sample of 428 pupils of ages 7–8 and 16–17 years old:^[28][29]

• 30% of the research population showed an allergy to nickel, and
• the allergy occurred in girls who had started wearing earrings in early childhood.

• Jura, Czesław; Krzanowska, Halina; Rzehak, Karol (1983). Podstawy embriologii zwierząt [Bases of Animals' Embryology] (1st ed.). Warsaw: Wydawnictwo Naukowe PWN (En.: Polish Scientific Publishers PWN). ISBN 83-01-04241-9.