Fibroblast growth factor receptor 4

Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334 (cluster of differentiation 334).

FGFR4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4QQ5, 4QQC, 4QQJ, 4QQT, 4QRC, 4R6V, 4TYE, 4TYG, 4TYI, 4TYJ, 4UXQ, 4XCU
Identifiers
Aliases	FGFR4, CD334, JTK2, TKF, fibroblast growth factor receptor 4
External IDs	OMIM: 134935; MGI: 95525; HomoloGene: 20461; GeneCards: FGFR4; OMA:FGFR4 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.2 Start 177,086,905 bp[1] End 177,098,144 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 B1|13 29.8 cM Start 55,300,453 bp[2] End 55,316,572 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver upper lobe of left lung right lung body of pancreas mucosa of transverse colon left ovary lower lobe of lung right ovary spleen right adrenal gland Top expressed in left lung lobe yolk sac left lobe of liver internal carotid artery utricle kidney urethra stria vascularis adrenal gland right lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity heparin binding kinase activity protein binding transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity fibroblast growth factor binding fibroblast growth factor-activated receptor activity ATP binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1-phosphatidylinositol-3-kinase activity receptor tyrosine kinase transmembrane signaling receptor activity Cellular component integral component of membrane endosome Golgi apparatus membrane cell-cell junction plasma membrane integral component of plasma membrane transport vesicle extracellular region endoplasmic reticulum cytoplasm receptor complex Biological process glucose homeostasis phosphorylation phosphate ion homeostasis response to bile acid regulation of extracellular matrix disassembly MAPK cascade regulation of bile acid biosynthetic process fibroblast growth factor receptor signaling pathway regulation of lipid metabolic process protein phosphorylation positive regulation of gene expression positive regulation of cell population proliferation positive regulation of DNA biosynthetic process positive regulation of ERK1 and ERK2 cascade positive regulation of proteolysis protein autophosphorylation peptidyl-tyrosine phosphorylation cell migration phosphatidylinositol phosphate biosynthetic process positive regulation of catalytic activity phosphatidylinositol-3-phosphate biosynthetic process positive regulation of protein kinase B signaling cholesterol homeostasis angiogenesis negative regulation of signal transduction cell differentiation negative regulation of apoptotic process transmembrane receptor protein tyrosine kinase signaling pathway nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2264 14186 Ensembl ENSG00000160867 ENSMUSG00000005320 UniProt P22455 Q03142 RefSeq (mRNA) NM_001291980 NM_002011 NM_022963 NM_213647 NM_001354984 NM_008011 RefSeq (protein) NP_001278909 NP_002002 NP_075252 NP_998812 NP_001341913 NP_032037 Location (UCSC) Chr 5: 177.09 – 177.1 Mb Chr 13: 55.3 – 55.32 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.^[5] In a meta-analisis study, the functional polymorphism Gly388Arg (rs351855) of FGFR4 was observed to be significantly associated with nodal involvement and overall survival in patients with different types of cancer.^[6]