Glycoprotein Ib (GPIb), also known as CD42,[1]is a component of the GPIb-V-IX complex on platelets. The GPIb-V-IX complex binds von Willebrand factor, allowing platelet adhesion and platelet plug formation at sites of vascular injury. Glycoprotein Ibα (GPIbα) is the major ligand-binding subunit of the GPIb-V-IX complex. GPIbα is heavily glycosylated.[2]
It is deficient in the Bernard–Soulier syndrome. A gain-of-function mutation causes platelet-type von Willebrand disease.[3]
Autoantibodies against Ib/IX can be produced in immune thrombocytopenic purpura.[4]
Components include GP1BA and GP1BB.
It complexes with Glycoprotein IX.
References
External links
- Glycoprotein+Ib at the U.S. National Library of Medicine Medical Subject Headings (MeSH)