Leukemia inhibitory factor receptor

LIFR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3E0G
Identifiers
Aliases	LIFR, CD118, LIF-R, SJS2, STWS, SWS, leukemia inhibitory factor receptor alpha, LIF receptor alpha, LIF receptor subunit alpha
External IDs	OMIM: 151443; MGI: 96788; HomoloGene: 1735; GeneCards: LIFR; OMA:LIFR - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	38,608,354 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	7,226,970 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; external globus pallidus; ; tibia; ; Achilles tendon; ; subthalamic nucleus; ; pons; ; cardia; ; lower lobe of lung; ; superficial temporal artery; ; inferior ganglion of vagus nerve;
	Top expressed in
	body of femur; ; sternocleidomastoid muscle; ; parotid gland; ; facial motor nucleus; ; triceps brachii muscle; ; temporal muscle; ; trigeminal ganglion; ; seminal vesicula; ; vastus lateralis muscle; ; pontine nuclei;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ciliary neurotrophic factor receptor activity; growth factor binding; oncostatin-M receptor activity; protein binding; cytokine receptor activity; ciliary neurotrophic factor receptor binding; leukemia inhibitory factor receptor activity; cytokine binding;
Cellular component	integral component of membrane; membrane; plasma membrane; receptor complex; integral component of plasma membrane; extracellular region; extracellular exosome; extracellular space; external side of plasma membrane;
Biological process	response to cytokine; leukemia inhibitory factor signaling pathway; oncostatin-M-mediated signaling pathway; cytokine-mediated signaling pathway; ciliary neurotrophic factor-mediated signaling pathway; cell surface receptor signaling pathway; positive regulation of cell population proliferation; regulation of cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3977
	16880
	ENSG00000113594
	ENSMUSG00000054263
	P42702
	P42703
	NM_001127671; NM_002310; NM_001364297; NM_001364298
	NM_001113386; NM_013584; NM_001358593
	NP_001121143; NP_002301; NP_001351226; NP_001351227
	NP_001106857; NP_038612; NP_001345522
	Wikidata
View/Edit Human	View/Edit Mouse

LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor.

Function

The leukemia inhibitory factor (LIF) is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, glycoprotein 130 (IL6ST, gp130). Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.^[5]

Interactions

Leukemia inhibitory factor receptor has been shown to interact with glycoprotein 130.^[6]^[7]

LIFR has also been identified as a breast cancer metastasis suppressor that functions through the Hippo-YAP pathway. LIFR is down regulated in a number of breast carcinomas and may serve a prognostic tool.

References

External links

LIF+Receptor+alpha+Subunit at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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Search

Leukemia inhibitory factor receptor

Contents

Function

Interactions

See also

References

Further reading

External links