Corbadrine

Corbadrine
Clinical data
ATC code	none;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 4-[(1R,2S)-2-amino-1-hydroxypropyl]benzene-1,2-diol;
CAS Number	829-74-3 ;
PubChem CID	164739;
IUPHAR/BPS	508;
DrugBank	DB06707 ;
ChemSpider	144416 ;
UNII	V008L6478D;
KEGG	D02388 ;
ChEMBL	ChEMBL677 ;
CompTox Dashboard (EPA)	DTXSID6046349 ;
ECHA InfoCard	100.113.606
Chemical and physical data
Formula	C9H13NO3
Molar mass	183.207 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc1ccc(cc1O)[C@@H](O)[C@@H](N)C;
	InChI InChI=1S/C9H13NO3/c1-5(10)9(13)6-2-3-7(11)8(12)4-6/h2-5,9,11-13H,10H2,1H3/t5-,9-/m0/s1 ; Key:GEFQWZLICWMTKF-CDUCUWFYSA-N ;
	(what is this?) (verify)

Corbadrine (INN; marketed as Neo-Cobefrine), also known as levonordefrin (USAN) and α-methylnorepinephrine, is a catecholamine sympathomimetic used as a topical nasal decongestant and vasoconstrictor in dentistry in the United States,^[1]^[2] (usually in a pre-mixed solution with local anesthetics, such as mepivacaine).^[3]

Corbadrine is also a metabolite of the antihypertensive drug methyldopa,^[4] and plays a role in its pharmacology and effects.

References

Nordefrin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Clinical data

ATC code	none
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 4-[(1R,2S)-2-amino-1-hydroxypropyl]benzene-1,2-diol
CAS Number	829-74-3^Y
PubChem CID	164739
IUPHAR/BPS	508
DrugBank	DB06707^Y
ChemSpider	144416^Y
UNII	V008L6478D
KEGG	D02388^Y
ChEMBL	ChEMBL677^Y
CompTox Dashboard (EPA)	DTXSID6046349
ECHA InfoCard	100.113.606
Chemical and physical data
Formula	C₉H₁₃NO₃
Molar mass	183.207 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Oc1ccc(cc1O)[C@@H](O)[C@@H](N)C
InChI InChI=1S/C9H13NO3/c1-5(10)9(13)6-2-3-7(11)8(12)4-6/h2-5,9,11-13H,10H2,1H3/t5-,9-/m0/s1^Y Key:GEFQWZLICWMTKF-CDUCUWFYSA-N^Y
^NY (what is this?) (verify)