Insulin receptor substrate (IRS) is an important ligand in the insulin response of human cells.
IRS-1, for example, is an IRS protein that contains a phosphotyrosine binding-domain (PTB-domain). In addition, the insulin receptor contains a NPXY motif. The PTB-domain binds the NPXY sequence. Thus, the insulin receptor binds IRS.
Genes
- IRS1 (see also Insulin receptor substrate 1)
- IRS2 (see also Insulin receptor substrate 2)
- IRS3P - a pseudogene
- IRS4
References
- van der Geer P, Wiley S, Pawson T (1999). "Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site". Oncogene. 18 (20): 3071–5. doi:10.1038/sj.onc.1202879. PMID 10340378.
🔥 Top keywords: Main PageSpecial:SearchWikipedia:Featured picturesYasukeHarrison ButkerRobert FicoBridgertonCleopatraDeaths in 2024Joyce VincentXXXTentacionHank AdamsIt Ends with UsYouTubeNew Caledonia2024 Indian general electionHeeramandiDarren DutchyshenSlovakiaKingdom of the Planet of the ApesAttempted assassination of Robert FicoLawrence WongBaby ReindeerXXX: Return of Xander CageThelma HoustonFuriosa: A Mad Max SagaMegalopolis (film)Richard GaddKepler's SupernovaWicked (musical)Sunil ChhetriXXX (2002 film)Ashley MadisonAnya Taylor-JoyPlanet of the ApesNava MauYoung SheldonPortal:Current eventsX-Men '97