COUP-TFI

NR2F1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EBL
Identifiers
Aliases	NR2F1, BBOAS, BBSOAS, COUP-TFI, EAR-3, EAR3, ERBAL3, NR2F2, SVP44, TCFCOUP1, TFCOUP1, nuclear receptor subfamily 2 group F member 1, COUPTF1
External IDs	OMIM: 132890; MGI: 1352451; HomoloGene: 21158; GeneCards: NR2F1; OMA:NR2F1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	93,594,611 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	78,347,876 bp
RNA expression pattern
	Top expressed in
	optic nerve; ; seminal vesicula; ; trigeminal ganglion; ; left uterine tube; ; germinal epithelium; ; ganglionic eminence; ; parietal pleura; ; lower lobe of lung; ; spinal ganglia; ; visceral pleura;
	Top expressed in
	lateral geniculate nucleus; ; barrel cortex; ; medial dorsal nucleus; ; vas deferens; ; saccule; ; ciliary body; ; subiculum; ; medial geniculate nucleus; ; ganglionic eminence; ; atrium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; steroid hormone receptor activity; sequence-specific DNA binding; transcription coactivator activity; DNA binding; nuclear receptor activity; zinc ion binding; protein binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; retinoic acid-responsive element binding;
Cellular component	nucleus; nucleoplasm; cytosol;
Biological process	transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; signal transduction; steroid hormone mediated signaling pathway; intracellular receptor signaling pathway; positive regulation of nucleic acid-templated transcription; nervous system development; negative regulation of neuron projection development; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	7025
	13865
	ENSG00000175745
	ENSMUSG00000069171
	P10589
	Q60632
	NM_005654
	NM_010151; NM_001347538; NM_001347539
	NP_005645
NP_001334467; NP_001334468; NP_034281; NP_001390702; NP_001390704;
	NP_001390706
	Wikidata
View/Edit Human	View/Edit Mouse

COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene.^[5]^[6] This protein is a member of nuclear hormone receptor family of steroid hormone receptors.

Function

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription.^[7]^[8] COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.^[9]

Interactions

COUP-TFI has been shown to interact with:

Clinical

Mutations in this gene have been associated with Bosch-Boonstra-Schaaf optic atrophy syndrome.^[13]

References

External links

Human NR2F1 genome location and NR2F1 gene details page in the UCSC Genome Browser.
Human NR2F2 genome location and NR2F2 gene details page in the UCSC Genome Browser.

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