Pafuramidine (formulated as the maleic acid salt pafuramidine maleate) is an experimental drug for the treatment of pneumocystis pneumonia (PCP). In 2006, pafuramidine was given orphan drug status by the US Food and Drug Administration for PCP in patients with HIV/AIDS.[1] Preliminary clinical trials indicated that pafuramide was effective against pneumocystis pneumonia and had the potential for fewer side effects than the standard treatment with trimethoprim/sulfamethoxazole (TMP-SMX).[2]
Names | |
---|---|
IUPAC name N′-Methoxy-4-[5-[4-[(Z)-N′-methoxycarbamimidoyl]phenyl]furan-2-yl]benzenecarboximidamide | |
Other names DB289 | |
Identifiers | |
3D model (JSmol) | |
ChEMBL | |
ChemSpider | |
PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
| |
| |
Properties | |
C20H20N4O3 | |
Molar mass | 364.405 g·mol−1 |
Pharmacology | |
Oral | |
Legal status |
|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Pafuramidine also reached Phase III clinical trials for the treatment of first stage African sleeping sickness, but development was halted in 2008 over concerns about kidney toxicity.[3][4]
References
🔥 Top keywords: Main PageSpecial:SearchWikipedia:Featured picturesYasukeHarrison ButkerRobert FicoBridgertonCleopatraDeaths in 2024Joyce VincentXXXTentacionHank AdamsIt Ends with UsYouTubeNew Caledonia2024 Indian general electionHeeramandiDarren DutchyshenSlovakiaKingdom of the Planet of the ApesAttempted assassination of Robert FicoLawrence WongBaby ReindeerXXX: Return of Xander CageThelma HoustonFuriosa: A Mad Max SagaMegalopolis (film)Richard GaddKepler's SupernovaWicked (musical)Sunil ChhetriXXX (2002 film)Ashley MadisonAnya Taylor-JoyPlanet of the ApesNava MauYoung SheldonPortal:Current eventsX-Men '97