Rauvolfia serpentina

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Rauvolfia serpentina, the Indian snakeroot, devil pepper, or serpentine wood,[4] is a species of flower in the milkweed family Apocynaceae.[5] It is native to the Indian subcontinent and East Asia (from India to Indonesia).[6][7]

Rauvolfia serpentina
CITES Appendix II (CITES)[1]
Scientific classification Edit this classification
Kingdom:Plantae
Clade:Tracheophytes
Clade:Angiosperms
Clade:Eudicots
Clade:Asterids
Order:Gentianales
Family:Apocynaceae
Genus:Rauvolfia
Species:
R. serpentina
Binomial name
Rauvolfia serpentina
Synonyms[3]
  • Ophioxylon album Gaertn.
  • Ophioxylon obversum Miq.
  • Ophioxylon salutiferum Salisb.
  • Ophioxylon serpentinum L.
  • Ophioxylon trifoliatum Gaertn.
  • Rauvolfia obversa (Miq.) Baill.
  • Rauvolfia trifoliata (Gaertn.) Baill.

Rauvolfia is a perennial undershrub widely distributed in India in the sub-Himalayan regions up to 1,000 metres (3,300 ft).

Chemical composition

Rauvolfia serpentina contains dozens of alkaloids of the indole alkaloid family, including ajmaline, ajmalicine, reserpine, and serpentine, among others.[5][8]

Research

A 2016 review found that reserpine reduced systolic blood pressure (SBP) by about 8 mmHg compared to placebo, and may be as effective at reducing SBP as other front-line hypertensive drugs, although more research is needed to determine a dose-specific safety profile.[9]

Potential adverse effects

R. serpentina may cause adverse effects by interacting with various prescription drugs[10] or via interference with mechanisms of mental depression or peptic ulcer.[10] The reserpine in R. serpentina is associated with diverse adverse effects, including vomiting, diarrhea, dizziness, headache, anxiety, or hypersensitivity reactions.[5]

See also

References