Folate transporter 1

SLC19A1
Identifiers
Aliases	SLC19A1, CHMD, FOLT, IFC1, REFC, RFC1, solute carrier family 19 member 1, IFC-1, RFC, hRFC, RFT-1, hMEGAF
External IDs	OMIM: 600424; MGI: 103182; HomoloGene: 57139; GeneCards: SLC19A1; OMA:SLC19A1 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	45,573,365 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	77,061,002 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; blood; ; endothelial cell; ; Epithelium of choroid plexus; ; retinal pigment epithelium; ; duodenum; ; gallbladder; ; stromal cell of endometrium; ; right lung; ; putamen;
	Top expressed in
	Paneth cell; ; right kidney; ; retinal pigment epithelium; ; vestibular membrane of cochlear duct; ; choroid plexus of fourth ventricle; ; ciliary body; ; Epithelium of choroid plexus; ; human kidney; ; crypt of lieberkuhn of small intestine; ; endothelial cell of lymphatic vessel;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	folic acid binding; methotrexate transmembrane transporter activity; vitamin transmembrane transporter activity; folic acid transmembrane transporter activity; folate:anion antiporter activity;
Cellular component	integral component of membrane; integral component of plasma membrane; apical plasma membrane; membrane; basolateral plasma membrane; plasma membrane;
Biological process	folic acid metabolic process; folate transmembrane transport; folic acid transport; methotrexate transport; vitamin transport; folate import across plasma membrane; transmembrane transport; vitamin transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6573
	20509
	ENSG00000173638
	ENSMUSG00000001436
	P41440
	P41438
NM_001205206; NM_001205207; NM_003056; NM_194255; NM_001352510;
	NM_001352511; NM_001352512
	NM_001199271; NM_031196
NP_001192135; NP_001192136; NP_919231; NP_001339439; NP_001339440;
	NP_001339441
	NP_001186200; NP_112473
	Wikidata
View/Edit Human	View/Edit Mouse

Folate transporter 1 is a protein which in humans is encoded by the SLC19A1 gene.^[5]

Function

Transport of folate compounds into mammalian cells can occur via receptor-mediated (see folate receptor 1) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.^[6] SLC19A1 has also been shown to transport the immune second messenger 2'3'-cGAMP.^[7]

Clinical significance

Individuals carrying a specific polymorphism of SLC19A1 (c.80GG) have lower levels of folate.^[8] Other studies have also shown that individuals carrying the c.80AA polymorphism who are treated with methotrexate have higher levels of this anti-folate chemotherapeutic agent. Personalized dosing of the drug depending on the patient's genotype may therefore be required.

Alternative names

Reduced folate carrier 1
Intestinal folate carrier 1

Search

Folate transporter 1

Contents

Function

Clinical significance

Alternative names

See also

References

Further reading