Mitochondrial 2-oxodicarboxylate carrier

SLC25A21
Identifiers
Aliases	SLC25A21, ODC, ODC1, solute carrier family 25 member 21, MTDPS18
External IDs	OMIM: 607571; MGI: 2445059; HomoloGene: 6988; GeneCards: SLC25A21; OMA:SLC25A21 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	37,172,606 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	57,244,257 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; stromal cell of endometrium; ; gastric mucosa; ; popliteal artery; ; tibial arteries; ; bone marrow; ; right testis; ; Achilles tendon; ; smooth muscle tissue;
	Top expressed in
	proximal tubule; ; bone marrow; ; right kidney; ; hepatobiliary system; ; liver; ; human kidney; ; spermatocyte; ; lobe of liver; ; morula; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	alpha-ketoglutarate transmembrane transporter activity; dicarboxylic acid transmembrane transporter activity; transmembrane transporter activity;
Cellular component	membrane; mitochondrion; mitochondrial inner membrane; integral component of membrane;
Biological process	transmembrane transport; lysine catabolic process; alpha-ketoglutarate transport; dicarboxylic acid transport; mitochondrial transport;
	Sources:Amigo / QuickGO
Orthologs
	89874
	217593
	ENSG00000183032
	ENSMUSG00000035472
	Q9BQT8
	Q8BZ09
	NM_001171170; NM_030631
	NM_001167976; NM_172577
	NP_001164641; NP_085134
	NP_001161448; NP_766165
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial 2-oxodicarboxylate carrier also known as solute carrier family 25 member 21 (SLC25A21) is a protein that in humans is encoded by the SLC25A21 gene.^[5]

It is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.^[5]

References

Fiermonte G, Dolce V, Palmieri L, Ventura M, Runswick MJ, Palmieri F, Walker JE (March 2001). "Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution, and chromosomal location". The Journal of Biological Chemistry. 276 (11): 8225–30. doi:10.1074/jbc.M009607200. PMID 11083877.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C (August 2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID 19240061. S2CID 17111427.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". American Journal of Human Genetics. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.

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Mitochondrial 2-oxodicarboxylate carrier

References

Further reading