Zinc transporter 1

SLC30A1
Identifiers
Aliases	SLC30A1, ZNT1, ZRC1, solute carrier family 30 member 1
External IDs	OMIM: 609521; MGI: 1345281; HomoloGene: 6681; GeneCards: SLC30A1; OMA:SLC30A1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	211,579,161 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	191,645,359 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; caput epididymis; ; Epithelium of choroid plexus; ; skin of thigh; ; trabecular bone; ; dorsal motor nucleus of vagus nerve; ; vulva; ; cartilage tissue; ; corpus epididymis; ; human penis;
	Top expressed in
	placenta; ; lip; ; ileum; ; renal cortex; ; proximal tubule; ; human kidney; ; primary oocyte; ; hair; ; secondary oocyte; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium channel inhibitor activity; cation transmembrane transporter activity; protein binding; zinc ion transmembrane transporter activity;
Cellular component	cytoplasm; integral component of membrane; Golgi apparatus; nuclear membrane; membrane; T-tubule; plasma membrane; endoplasmic reticulum; Schaffer collateral - CA1 synapse; integral component of postsynaptic density membrane;
Biological process	negative regulation of neurotransmitter secretion; calcium ion import; zinc ion transport; cellular calcium ion homeostasis; response to zinc ion; cation transport; in utero embryonic development; ion transport; negative regulation of calcium ion import; detoxification of cadmium ion; negative regulation of zinc ion transmembrane import; zinc ion transmembrane transport; cellular zinc ion homeostasis; cadmium ion transmembrane transport; regulation of sequestering of zinc ion; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	7779
	22782
	ENSG00000170385
	ENSMUSG00000037434
	Q9Y6M5
	Q60738
	NM_021194
	NM_009579
	NP_067017
	NP_033605
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc transporter 1 is a protein which in humans is encoded by the SLC30A1 gene.^[5]^[6]

Function

SLC30A1 modulates zinc permeation through the L-type calcium channel. SLC30A1 downregulates not only Zn⁺⁺ influx, but also Ca⁺⁺ influx, thereby protecting cells from the effects of excessive cation permeation.^[7]

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Zinc transporter 1

Contents

Function

See also

References

Further reading