Solute carrier family 30 member 10

SLC30A10
Identifiers
Aliases	SLC30A10, HMDPC, ZNT10, ZNT8, ZRC1, ZnT-10, solute carrier family 30 member 10, HMNDYT1
External IDs	OMIM: 611146; MGI: 2685058; HomoloGene: 100946; GeneCards: SLC30A10; OMA:SLC30A10 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	219,959,018 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	185,200,959 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; right lobe of liver; ; mucosa of transverse colon; ; endothelial cell; ; duodenum; ; Epithelium of choroid plexus; ; retinal pigment epithelium; ; testicle; ; buccal mucosa cell; ; mucosa of sigmoid colon;
	Top expressed in
	duodenum; ; lumbar subsegment of spinal cord; ; ventricular zone; ; liver; ; left lobe of liver; ; epithelium of small intestine; ; ganglionic eminence; ; embryo; ; jejunum; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	cation transmembrane transporter activity; zinc ion transmembrane transporter activity; protein binding; manganese ion transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; endosome; early endosome; Golgi apparatus; recycling endosome; plasma membrane;
Biological process	regulation of sequestering of zinc ion; manganese ion transport; response to zinc ion; cation transport; zinc ion transport; ion transport; transmembrane transport; zinc ion transmembrane transport; epidermal growth factor receptor signaling pathway; negative regulation of neuron apoptotic process; positive regulation of ERK1 and ERK2 cascade; manganese ion transmembrane transport; regulation of zinc ion transport; negative regulation of reactive oxygen species biosynthetic process; cellular response to angiotensin; regulation of cellular response to manganese ion; negative regulation of cellular senescence; cation transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	55532
	226781
	ENSG00000196660
	ENSMUSG00000026614
	Q6XR72
	Q3UVU3
	NM_001004433; NM_018713; NM_001376929
	NM_001033286
	NP_061183; NP_001363858; NP_061183.2
	NP_001028458
	Wikidata
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Solute carrier family 30 member 10 is a protein that in humans is encoded by the SLC30A10 gene.^[5]

Function

This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012].

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Solute carrier family 30 member 10

Function

References

Further reading