Bile salt sulfotransferase

SULT2A1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1EFH, 1J99, 1OV4, 2QP3, 2QP4, 3F3Y, 4IFB
Identifiers
Aliases	SULT2A1, DHEA-ST, DHEAS, HST, ST2, ST2A1, ST2A3, STD, hSTa, sulfotransferase family 2A member 1, DHEA-ST8, SULT2A3
External IDs	OMIM: 125263; MGI: 3645854; HomoloGene: 37741; GeneCards: SULT2A1; OMA:SULT2A1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	47,886,315 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	13,723,532 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; right lobe of liver; ; duodenum; ; seminal vesicula; ; cardia; ; body of stomach; ; fundus; ; amniotic fluid; ; urinary bladder; ; metanephros;
	Top expressed in
	secondary oocyte; ; spermatocyte; ; spermatid; ; gonad; ; testicle; ; liver;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; protein binding; estrone sulfotransferase activity; aryl sulfotransferase activity; steroid sulfotransferase activity; bile-salt sulfotransferase activity;
Cellular component	cytoplasm; cytosol;
Biological process	lipid catabolic process; bile acid catabolic process; sulfation; lipid metabolism; ethanol catabolic process; regulation of lipid metabolic process; 3'-phosphoadenosine 5'-phosphosulfate metabolic process; steroid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	6822
	434121
	ENSG00000105398
	ENSMUSG00000074377
	Q06520
	n/a
	NM_003167
	NM_001101534
	NP_003158
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the SULT2A1 gene.^[5]^[6]^[7]

Function

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene is primarily expressed in liver and adrenal tissues where the encoded protein sulfonates steroids and bile acids.^[5]

References

External links

alcohol+sulfotransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human SULT2A1 genome location and SULT2A1 gene details page in the UCSC Genome Browser.

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Bile salt sulfotransferase

Contents

Function

See also

References

Further reading

External links