Thrombospondin 3

Thrombospondin-3 (TSP3) is a protein that in humans is encoded by the THBS3 gene.^[5][6]

THBS3
Identifiers
Aliases	THBS3, TSP3, thrombospondin 3
External IDs	OMIM: 188062; MGI: 98739; HomoloGene: 5159; GeneCards: THBS3; OMA:THBS3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 155,195,588 bp[1] End 155,209,051 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.01 cM Start 89,122,487 bp[2] End 89,134,144 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube tibia body of uterus right testis left testis right coronary artery left uterine tube tibial nerve tendon of biceps brachii canal of the cervix Top expressed in ventricular zone spermatocyte pulmonary alveolar epithelium lip ankle right lung lobe ankle joint esophagus efferent ductule spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding heparin binding extracellular matrix structural constituent Cellular component perinuclear region of cytoplasm extracellular region extracellular matrix extracellular space collagen-containing extracellular matrix Biological process growth plate cartilage development ossification involved in bone maturation cell-matrix adhesion cell adhesion bone trabecula formation extracellular matrix organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7059 21827 Ensembl ENSG00000169231 ENSMUSG00000028047 UniProt P49746 Q05895 RefSeq (mRNA) NM_001252607 NM_001252608 NM_007112 NM_013691 RefSeq (protein) NP_001239536 NP_001239537 NP_009043 NP_038719 Location (UCSC) Chr 1: 155.2 – 155.21 Mb Chr 3: 89.12 – 89.13 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. TSP3 has been found to be involved in the regulation of skeletal maturation.^[7] This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1.^[6] Identified as the gene on chromosome 1 responsible for mediating an associated with genetic susceptibility to SARS-CoV-2 infection.^[8]