Thrombospondin 4

Thrombospondin-4 is a protein that in humans is encoded by the THBS4 gene.^[5][6]

THBS4
Identifiers
Aliases	THBS4, TSP4, TSP-4, thrombospondin 4
External IDs	OMIM: 600715; MGI: 1101779; HomoloGene: 20691; GeneCards: THBS4; OMA:THBS4 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q14.1 Start 79,991,311 bp[1] End 80,083,287 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 C3|13 47.75 cM Start 92,888,098 bp[2] End 92,931,326 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon synovial joint pericardium synovial membrane tibial nerve body of tongue vena cava secondary oocyte urethra triceps brachii muscle Top expressed in ankle left colon sciatic nerve lip body of femur soleus muscle intercostal muscle tibialis anterior muscle quadriceps femoris muscle cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparin binding integrin binding protein binding growth factor activity calcium ion binding Cellular component basement membrane extracellular exosome extracellular region sarcoplasmic reticulum extracellular matrix endoplasmic reticulum extracellular space collagen-containing extracellular matrix Biological process myoblast migration positive regulation of endothelial cell proliferation endothelial cell-cell adhesion response to unfolded protein cell adhesion positive regulation of neutrophil chemotaxis positive regulation of peptidyl-tyrosine phosphorylation negative regulation of angiogenesis tissue remodeling positive regulation of cell division response to endoplasmic reticulum stress regulation of tissue remodeling behavioral response to pain regulation of signaling receptor activity signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7060 21828 Ensembl ENSG00000113296 ENSMUSG00000021702 UniProt P35443 Q9Z1T2 RefSeq (mRNA) NM_001306212 NM_001306213 NM_001306214 NM_003248 NM_011582 RefSeq (protein) NP_001293141 NP_001293142 NP_001293143 NP_003239 NP_035712 Location (UCSC) Chr 5: 79.99 – 80.08 Mb Chr 13: 92.89 – 92.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. This protein may be involved in local signaling in the developing and adult nervous system, in bone formation and fracture healing, and in osteoarthritis.^[6]