I think that a 16th-century work is interesting in its own right, but this one also illustrates a fascinating bit of mediaeval Christian mythology. It is (arguably - I am NOT a fan of the Yorck Project's rather slapshod work) the only high-quality image in Tiburtine Sibyl, and, as Wikipedia's only work by Antonio da Trento, is our sole image for illustrating discussion of him.
Note: A version of this, under the same filename, was nominated before, while unopposed, it did not reach quorum. This is, however, a completely rethought restoration. As this is five centuries old, there's some extensive damage, some of it not really practical to repair, but I can improve it significantly.