North Carolina elected its members August 15, 1806.
| District | Incumbent | Party | First elected | Result | Candidates[a] |
|---|---|---|---|---|---|
| North Carolina 1 | Thomas Wynns | Democratic-Republican | 1802 (Special) | Incumbent retired. New member elected. Democratic-Republican hold. | √ Lemuel Sawyer (Democratic-Republican) 64.0% William H. Murfree (Democratic-Republican) 36.0% |
| North Carolina 2 | Willis Alston | Democratic-Republican | 1798 | Incumbent re-elected. | √ Willis Alston (Democratic-Republican) Unopposed |
| North Carolina 3 | Thomas Blount | Democratic-Republican | 1793 1804 | Incumbent re-elected. | √ Thomas Blount (Democratic-Republican) 50.1%[b] William Kennedy (Democratic-Republican) 49.9% |
| North Carolina 4 | William Blackledge | Democratic-Republican | 1803 | Incumbent re-elected. | √ William Blackledge (Democratic-Republican)[c] |
| North Carolina 5 | Thomas Kenan | Democratic-Republican | 1805 (Special) | Incumbent re-elected. | √ Thomas Kenan (Democratic-Republican)[c] Benjamin Smith (Democratic-Republican) Samuel Jacelyn Alexander D. Moore |
| North Carolina 6 | Nathaniel Macon | Democratic-Republican | 1791 | Incumbent re-elected. | √ Nathaniel Macon (Democratic-Republican) 99.8% |
| North Carolina 7 | Duncan McFarlan | Democratic-Republican | 1804 | Incumbent lost re-election. New member elected. Federalist gain. Election was later contested. | √ John Culpepper (Federalist) 48.1% Duncan McFarlan (Democratic-Republican) 47.2% John Hay (Federalist) 3.7% James Sanders (Democratic-Republican) 1.0% |
| North Carolina 8 | Richard Stanford | Democratic-Republican | 1796 | Incumbent re-elected. | √ Richard Stanford (Democratic-Republican) 94.3% Calvin Jones 2.6% |
| North Carolina 9 | Marmaduke Williams | Democratic-Republican | 1803 | Incumbent re-elected. | √ Marmaduke Williams (Democratic-Republican) 57.9% Theophilus Lacy (Democratic-Republican) 42.1% |
| North Carolina 10 | Evan S. Alexander | Democratic-Republican | 1806 (Special) | Incumbent re-elected. | √ Evan S. Alexander[c] Matthew Brandon |
| North Carolina 11 | James Holland | Democratic-Republican | 1800 | Incumbent re-elected. | √ James Holland (Democratic-Republican) 96.1% Joseph Graham 3.7% |
| North Carolina 12 | Joseph Winston | Democratic-Republican | 1803 | Incumbent retired. New member elected. Democratic-Republican hold. | √ Meshack Franklin (Democratic-Republican) 63.1% William Lenoir (Democratic-Republican) 32.5% Peter Eaton (Democratic-Republican) 4.4% |