1980–81 Coupe de France

The Coupe de France 1980–81 was its 64th edition. It was won by SC Bastia which defeated AS Saint-Étienne in the Final.

Round of 16

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
SEC Bastia (D1)	3–2	AS Monaco (D1)	2–0	1–2
FC Nantes (D1)	5–10	Girondins de Bordeaux (D1)	1–4	4–6
AS Nancy (D1)	3–4	AS Saint-Étienne (D1)	2–1	1–3
LB Châteauroux (D2)	1–2	Lille OSC (D1)	1–0	0–2
Le Havre AC (D2)	1–2	RC Lens (D1)	1–0	0–2
FC Metz (D1)	2–2 (a)	Montpellier HSC (D2)	2–1	0–1
RC Strasbourg (D1)	3–2	AS Angoulême (D2)	2–0	1–2
Thionville FC (D2)	2–5	FC Martigues (D2)	2–2	0–3

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
RC Lens (D1)	3–2	Lille OSC (D1)	3–1	0–1
Girondins de Bordeaux (D1)	1–9	RC Strasbourg (D1)	1–5	0–4
AS Saint-Étienne (D1)	3–2	Montpellier HSC (D2)	2–1	1–1
FC Martigues (D2)	3–5	SEC Bastia (D1)	3–0	0–5