Lisa Raymond and Mike Bryan were the defending champions, but lost in the quarterfinals to Cara Black and Wayne Black.
| Mixed doubles | |
|---|---|
| 2003 US Open | |
| Champions |  Katarina Srebotnik Bob Bryan |
| Runners-up |  Lina Krasnoroutskaya Daniel Nestor |
| Score | 5–7, 7–5, [10–5] |
Katarina Srebotnik and Bob Bryan won the title, defeating Lina Krasnoroutskaya and Daniel Nestor in the final 5–7, 7–5, [10–5].
Seeds
Paola Suárez / 
Mahesh Bhupathi (second round, withdrew)
Lisa Raymond / Mike Bryan (quarterfinals)
Virginia Ruano Pascual / 
Mark Knowles (quarterfinals)
Elena Likhovtseva / 
Todd Woodbridge (second round)- Lina Krasnoroutskaya /
Daniel Nestor (final) 
Janette Husárová / 
Leoš Friedl (semifinal)
Cara Black / Wayne Black (semifinal)
Katarina Srebotnik / Bob Bryan (champions)
Draw
Key
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
Finals
| Semifinals | Final | ||||||||||||
| 6 |  Janette Husárová Leoš Friedl | 1 | 3 | ||||||||||
| 8 | Katarina Srebotnik Bob Bryan | 6 | 6 | ||||||||||
| 8 | Katarina Srebotnik Bob Bryan | 5 | 7 | [10] | |||||||||
| 5 | Lina Krasnoroutskaya Daniel Nestor | 7 | 5 | [5] | |||||||||
| 5 | Lina Krasnoroutskaya Daniel Nestor | 77 | 77 | ||||||||||
| 7 |  Cara Black Wayne Black | 62 | 65 | ||||||||||
Top half
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 |  P Suárez M Bhupathi | 67 | 6 | [10] | |||||||||||||||||||||||
 P Mandula G Oliver | 79 | 4 | [6] | 1 | P Suárez M Bhupathi | ||||||||||||||||||||||
 L Huber P Vízner | 6 | 6 | L Huber P Vízner | w/o | |||||||||||||||||||||||
 E Gagliardi D Rikl | 3 | 2 | L Huber P Vízner | 5 | 4 | ||||||||||||||||||||||
 N Miyagi C Suk | 5 | 6 | [10] | 6 | J Husárová L Friedl | 7 | 6 | ||||||||||||||||||||
 J Dokic N Zimonjić | 7 | 3 | [5] | N Miyagi C Suk | 3 | 6 | [5] | ||||||||||||||||||||
| WC | M Washington J Tarango | 4 | 4 | 6 | J Husárová L Friedl | 6 | 3 | [10] | |||||||||||||||||||
| 6 | J Husárová L Friedl | 6 | 6 | 6 | J Husárová L Friedl | 1 | 3 | ||||||||||||||||||||
| 3 |  V Ruano Pascual M Knowles | 6 | 6 | 8 | K Srebotnik B Bryan | 6 | 6 | ||||||||||||||||||||
| WC | A Cargill B Vahaly | 1 | 2 | 3 | V Ruano Pascual M Knowles | w/o | |||||||||||||||||||||
| WC | M Shaughnessy R Leach | 5 | 6 | [10] | WC | M Shaughnessy R Leach | |||||||||||||||||||||
C Rubin J Björkman | 7 | 4 | [5] | 3 | V Ruano Pascual M Knowles | 6 | 2 | [7] | |||||||||||||||||||
 P Wartusch F Čermák | 3 | 3 | 8 | K Srebotnik B Bryan | 2 | 6 | [10] | ||||||||||||||||||||
 R Stubbs D Johnson | 6 | 6 | R Stubbs D Johnson | 6 | 3 | [6] | |||||||||||||||||||||
 E Callens G Etlis | 3 | 66 | 8 | K Srebotnik B Bryan | 4 | 6 | [10] | ||||||||||||||||||||
| 8 | K Srebotnik B Bryan | 6 | 78 | ||||||||||||||||||||||||
Bottom half
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | L Krasnoroutskaya D Nestor | 6 | 7 | ||||||||||||||||||||||||
| D Hantuchová K Ullyett | 4 | 5 | 5 | L Krasnoroutskaya D Nestor | 7 | 6 | |||||||||||||||||||||
 M Vento-Kabchi M Hood | 6 | 6 | M Vento-Kabchi M Hood | 5 | 3 | ||||||||||||||||||||||
 A Pistolesi J Coetzee | 2 | 4 | 5 | L Krasnoroutskaya D Nestor | 6 | 6 | |||||||||||||||||||||
| WC | A Stevenson V Spadea | 78 | 2 | [10] | WC | A Stevenson V Spadea | 1 | 1 | |||||||||||||||||||
| V Zvonareva J Eagle | 66 | 6 | [8] | WC | A Stevenson V Spadea | 6 | 65 | [10] | |||||||||||||||||||
| WC | C Morariu J Gimelstob | 0 | 5 | 4 | E Likhovtseva T Woodbridge | 1 | 77 | [8] | |||||||||||||||||||
| 4 | E Likhovtseva T Woodbridge | 6 | 7 | 5 | L Krasnoroutskaya D Nestor | 77 | 77 | ||||||||||||||||||||
| 7 | C Black W Black | 7 | 6 | 7 | C Black W Black | 62 | 65 | ||||||||||||||||||||
| D Chládková M Damm | 5 | 0 | 7 | C Black W Black | 4 | 77 | [10] | ||||||||||||||||||||
 E Daniilidou C Haggard | 6 | 78 | E Daniilidou C Haggard | 6 | 65 | [5] | |||||||||||||||||||||
| WC | A Harkleroad A Bogomolov Jr. | 3 | 66 | 7 | C Black W Black | 77 | 6 | ||||||||||||||||||||
 J Lee J Palmer | 2 | 7 | [10] | 2 | L Raymond M Bryan | 64 | 2 | ||||||||||||||||||||
| A Myskina B MacPhie | 6 | 5 | [7] | J Lee J Palmer | 0 | 1 | |||||||||||||||||||||
| N Pratt P Hanley | 3 | 5 | 2 | L Raymond M Bryan | 6 | 6 | |||||||||||||||||||||
| 2 | L Raymond M Bryan | 6 | 7 | ||||||||||||||||||||||||
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