77-LH-28-1

77-LH-28-1
Identifiers
	IUPAC name 1-[3-(4-butylpiperidin-1-yl)propyl]-3,4-dihydroquinolin-2-one;
CAS Number	560085-11-2;
PubChem CID	10236758;
IUPHAR/BPS	3271;
ChemSpider	8412246;
CompTox Dashboard (EPA)	DTXSID90437063 ;
Chemical and physical data
Formula	C21H32N2O
Molar mass	328.500 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2N(c1ccccc1CC2)CCCN3CCC(CC3)CCCC;
	InChI InChI=1S/C21H32N2O/c1-2-3-7-18-12-16-22(17-13-18)14-6-15-23-20-9-5-4-8-19(20)10-11-21(23)24/h4-5,8-9,18H,2-3,6-7,10-17H2,1H3; Key:PHMGZAICAOYEAF-UHFFFAOYSA-N;

77-LH-28-1 is a selective agonist of muscarinic acetylcholine receptor subtype 1 (M₁) discovered in 2008. It is an allosteric agonist, exhibiting over 100-fold specificity for M₁ over other muscarinic receptor subtypes. 77-LH-28-1 penetrates the brain by crossing the blood–brain barrier and is therefore a useful pharmacological tool with cognition enhancing effects.^[1]

References

[1]

Identifiers

IUPAC name 1-[3-(4-butylpiperidin-1-yl)propyl]-3,4-dihydroquinolin-2-one
CAS Number	560085-11-2
PubChem CID	10236758
IUPHAR/BPS	3271
ChemSpider	8412246
CompTox Dashboard (EPA)	DTXSID90437063
Chemical and physical data
Formula	C₂₁H₃₂N₂O
Molar mass	328.500 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C2N(c1ccccc1CC2)CCCN3CCC(CC3)CCCC
InChI InChI=1S/C21H32N2O/c1-2-3-7-18-12-16-22(17-13-18)14-6-15-23-20-9-5-4-8-19(20)10-11-21(23)24/h4-5,8-9,18H,2-3,6-7,10-17H2,1H3 Key:PHMGZAICAOYEAF-UHFFFAOYSA-N