ABCF1

ATP-binding cassette sub-family F member 1 is a protein that in humans is encoded by the ABCF1 gene.^[5][6]

ABCF1
Identifiers
Aliases	ABCF1, ABC27, ABC50, ATP binding cassette subfamily F member 1
External IDs	OMIM: 603429; MGI: 1351658; HomoloGene: 849; GeneCards: ABCF1; OMA:ABCF1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 30,571,393 bp[1] End 30,597,179 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 18.8 cM Start 36,267,711 bp[2] End 36,280,653 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gastrocnemius muscle skeletal muscle tissue islet of Langerhans placenta stromal cell of endometrium skin of abdomen smooth muscle tissue lymph node body of stomach Top expressed in yolk sac condyle primitive streak lacrimal gland fossa aortic valve internal carotid artery somite hair follicle Paneth cell More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding ribosome binding translation activator activity translation factor activity, RNA binding ATPase activity protein binding ATP binding RNA binding Cellular component cytoplasm ribosome nuclear envelope membrane nucleoplasm nucleus polysomal ribosome cytosol Biological process protein biosynthesis ribosome biogenesis positive regulation of translation transmembrane transport translational initiation inflammatory response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23 224742 Ensembl ENSG00000206490 ENSG00000225989 ENSG00000236149 ENSG00000232169 ENSG00000204574 ENSG00000236342 ENSG00000231129 ENSMUSG00000038762 UniProt Q8NE71 Q6P542 RefSeq (mRNA) NM_001090 NM_001025091 NM_013854 RefSeq (protein) NP_001020262 NP_001081 NP_038882 Location (UCSC) Chr 6: 30.57 – 30.6 Mb Chr 17: 36.27 – 36.28 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process.^[6]