ATP11C

ATP11C
Identifiers
Aliases	ATP11C, ATPIG, ATPIQ, ATPase phospholipid transporting 11C, HACXL
External IDs	OMIM: 300516; MGI: 1859661; HomoloGene: 27862; GeneCards: ATP11C; OMA:ATP11C - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	139,945,276 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	59,636,304 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; Achilles tendon; ; liver; ; parietal pleura; ; superficial temporal artery; ; visceral pleura; ; right lobe of liver; ; germinal epithelium; ; lymph node; ; pancreatic epithelial cell;
	Top expressed in
	liver; ; secondary oocyte; ; ganglionic eminence; ; uterus; ; thymus; ; spermatid; ; ovary; ; mesencephalon; ; lens; ; cerebellar cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; metal ion binding; protein binding; hydrolase activity; ATP binding; magnesium ion binding; ATPase-coupled intramembrane lipid transporter activity;
Cellular component	integral component of membrane; recycling endosome; endoplasmic reticulum membrane; membrane; plasma membrane; lysosomal membrane; endoplasmic reticulum; trans-Golgi network;
Biological process	pre-B cell differentiation; lipid transport; positive regulation of B cell differentiation; phospholipid transport; ion transmembrane transport; phospholipid translocation; transport;
	Sources:Amigo / QuickGO
Orthologs
	286410
	320940
	ENSG00000101974
	ENSMUSG00000062949
	Q8NB49
	Q9QZW0
	NM_001010986; NM_173694; NM_001353810; NM_001353811; NM_001353812
	NM_001001798; NM_001037863; NM_001359002
	NP_001010986; NP_775965; NP_001340739; NP_001340740; NP_001340741
	NP_001001798; NP_001032952; NP_001345931
	Wikidata
View/Edit Human	View/Edit Mouse

ATP11C is an enzyme that in humans is encoded by the ATP11C gene.

Function

ATP11C encodes a member of the Type IV P-type ATPase family that is thought to transport or 'flip' aminophospholipids. The corresponding protein in mice is essential for the development of B cells and red blood cells,^[5]^[6] and for the prevention of intrahepatic cholestasis.^[7]

References

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