ATP1B1

Sodium/potassium-transporting ATPase subunit beta-1 is an enzyme that in humans is encoded by the ATP1B1 gene.^[5]

ATP1B1
Identifiers
Aliases	ATP1B1, ATP1B, ATPase Na+/K+ transporting subunit beta 1
External IDs	OMIM: 182330; MGI: 88108; HomoloGene: 37509; GeneCards: ATP1B1; OMA:ATP1B1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q24.2 Start 169,105,697 bp[1] End 169,310,992 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H2.2|1 71.75 cM Start 164,264,678 bp[2] End 164,285,924 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla pons superior vestibular nucleus external globus pallidus Brodmann area 23 postcentral gyrus ventral tegmental area inferior ganglion of vagus nerve kidney tubule Region I of hippocampus proper Top expressed in olfactory tubercle medial vestibular nucleus left colon amygdala nucleus accumbens subiculum medial dorsal nucleus cerebellar vermis prefrontal cortex lateral geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase binding potassium ion binding sodium ion binding P-type sodium:potassium-exchanging transporter activity ATPase activity protein C-terminus binding protein binding MHC class II protein complex binding ATPase activator activity ATP binding protein kinase binding Cellular component extracellular vesicle integral component of membrane membrane intercalated disc myelin sheath plasma membrane intracellular anatomical structure sodium:potassium-exchanging ATPase complex basolateral plasma membrane apical plasma membrane caveola sarcolemma extracellular exosome Biological process regulation of cardiac conduction regulation of cardiac muscle contraction by calcium ion signaling response to hypoxia positive regulation of ATP-dependent activity cardiac muscle contraction positive regulation of sodium ion export across plasma membrane sodium ion transport cellular sodium ion homeostasis sodium ion export across plasma membrane metal ion transport cell communication by electrical coupling involved in cardiac conduction protein stabilization positive regulation of potassium ion import across plasma membrane cellular calcium ion homeostasis ion transport cellular potassium ion homeostasis potassium ion transport membrane repolarization ion transmembrane transport ATP metabolic process cell adhesion regulation of gene expression positive regulation of calcium:sodium antiporter activity protein localization to plasma membrane membrane repolarization during cardiac muscle cell action potential relaxation of cardiac muscle regulation of calcium ion transmembrane transport leukocyte migration positive regulation of potassium ion transmembrane transporter activity protein transport into plasma membrane raft potassium ion import across plasma membrane establishment or maintenance of transmembrane electrochemical gradient transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 481 11931 Ensembl ENSG00000143153 ENSMUSG00000026576 UniProt P05026 P14094 RefSeq (mRNA) NM_001677 NM_001001787 NM_009721 RefSeq (protein) NP_001668 NP_033851 Location (UCSC) Chr 1: 169.11 – 169.31 Mb Chr 1: 164.26 – 164.29 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to the family of Na⁺/K⁺ and H⁺/K⁺ ATPases beta chain proteins, and to the subfamily of Na⁺/K⁺-ATPases. Na⁺/K⁺-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na⁺/K⁺-ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.^[5]