ATP2B3

Plasma membrane calcium-transporting ATPase 3 (PMCA3) is an enzyme that in humans is encoded by the ATP2B3 gene.^[5][6]

ATP2B3
Identifiers
Aliases	ATP2B3, CFAP39, CLA2, OPCA, PMCA3, PMCA3a, SCAX1, ATPase plasma membrane Ca2+ transporting 3
External IDs	OMIM: 300014; MGI: 1347353; HomoloGene: 123775; GeneCards: ATP2B3; OMA:ATP2B3 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 153,517,642 bp[1] End 153,582,939 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A7.3 Start 72,546,692 bp[2] End 72,614,611 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus frontal pole superior frontal gyrus cerebellar vermis postcentral gyrus dorsolateral prefrontal cortex Brodmann area 10 entorhinal cortex Top expressed in cerebellar cortex hippocampus proper superior frontal gyrus hypothalamus adrenal gland basal forebrain secondary oocyte olfactory bulb muscle tissue skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding nucleotide binding hydrolase activity PDZ domain binding calmodulin binding ATP binding P-type calcium transporter activity protein binding calcium ion transmembrane transporter activity P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration Cellular component extracellular vesicle integral component of membrane Golgi apparatus intracellular membrane-bounded organelle integral component of plasma membrane membrane plasma membrane presynapse glutamatergic synapse GABA-ergic synapse Biological process calcium ion transport regulation of cardiac conduction cellular calcium ion homeostasis ion transport calcium ion transmembrane transport ion transmembrane transport transport regulation of cytosolic calcium ion concentration regulation of presynaptic cytosolic calcium ion concentration calcium ion export across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 492 320707 Ensembl ENSG00000067842 ENSMUSG00000031376 UniProt Q16720 n/a RefSeq (mRNA) NM_001001344 NM_021949 NM_001388360 NM_001388361 NM_001388362 NM_177236 NM_001310537 RefSeq (protein) NP_001001344 NP_068768 n/a Location (UCSC) Chr X: 153.52 – 153.58 Mb Chr X: 72.55 – 72.61 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified.^[6]