ATP8B3

ATP8B3
Identifiers
Aliases	ATP8B3, ATPIK, ATPase phospholipid transporting 8B3
External IDs	OMIM: 605866; MGI: 1914581; HomoloGene: 19034; GeneCards: ATP8B3; OMA:ATP8B3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,812,276 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,374,958 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right adrenal gland; ; left adrenal gland; ; spleen; ; sperm; ; monocyte; ; bone marrow cells; ; blood; ; vagina; ; amniotic fluid;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; olfactory epithelium; ; facial motor nucleus; ; islet of Langerhans; ; anterior horn of spinal cord; ; submandibular gland; ; adrenal gland; ; olfactory bulb;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; metal ion binding; ATPase-coupled intramembrane lipid transporter activity; hydrolase activity; ATP binding; magnesium ion binding;
Cellular component	integral component of membrane; Golgi apparatus; endoplasmic reticulum membrane; membrane; plasma membrane; acrosomal membrane; endoplasmic reticulum; cytoplasmic vesicle; acrosomal vesicle;
Biological process	lipid transport; Golgi organization; phospholipid transport; phospholipid translocation; binding of sperm to zona pellucida;
	Sources:Amigo / QuickGO
Orthologs
	148229
	67331
	ENSG00000130270
	ENSMUSG00000003341
	O60423
	Q6UQ17
	NM_001178002; NM_138813
	NM_026094
	NP_001171473; NP_620168
	NP_080370
	Wikidata
View/Edit Human	View/Edit Mouse

The human gene ATP8B3 encodes the protein ATPase, aminophospholipid transporter, class I, type 8B, member 3.^[5]

Transcript

Alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[5]

Protein

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene encodes the member 3 of the phospholipid-transporting ATPase 8B.

References

External links

Human ATP8B3 genome location and ATP8B3 gene details page in the UCSC Genome Browser.

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ATP8B3

Contents

Transcript

Protein

References

External links

Further reading