CD98 is a glycoprotein[1][2] that is a heterodimer composed of SLC3A2 and SLC7A5 that forms the large neutral amino acid transporter (LAT1). LAT1 is a heterodimeric membrane transport protein that preferentially transports branched-chain (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine, phenylalanine) amino acids.[3] LAT is highly expressed in brain capillaries (which form the blood–brain barrier) relative to other tissues.[3]
| solute carrier family 3 member 2 (activators of dibasic and neutral amino acid transport) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | SLC3A2 | ||||||
| Alt. symbols | MDU1, 4T2HC, 4F2, NACAE, CD98 | ||||||
| NCBI gene | 6520 | ||||||
| HGNC | 11026 | ||||||
| OMIM | 158070 | ||||||
| RefSeq | NM_001013251 | ||||||
| UniProt | P08195 | ||||||
| Other data | |||||||
| Locus | Chr. 11 q12-q22 | ||||||
| |||||||
| solute carrier family 7 member 5 (cationic amino acid transporter, y+ system) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | SLC7A5 | ||||||
| Alt. symbols | LAT1, E16, D16S469E, MPE16, CD98 | ||||||
| NCBI gene | 8140 | ||||||
| HGNC | 11063 | ||||||
| OMIM | 600182 | ||||||
| RefSeq | NM_003486 | ||||||
| UniProt | Q01650 | ||||||
| Other data | |||||||
| Locus | Chr. 16 q24.3 | ||||||
| |||||||
A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:
See also
References
External links
- CD98+Antigens at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Large+Neutral+Amino+Acid-Transporter+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Amino+Acid+Transport+System+L at the U.S. National Library of Medicine Medical Subject Headings (MeSH)