CPLX2

Complexin-2 is a protein that in humans is encoded by the CPLX2 gene.^[5][6][7]

CPLX2
Identifiers
Aliases	CPLX2, 921-L, CPX-2, CPX2, Hfb1, complexin 2
External IDs	OMIM: 605033; MGI: 104726; HomoloGene: 38212; GeneCards: CPLX2; OMA:CPLX2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.2 Start 175,796,310 bp[1] End 175,884,021 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B1 Start 54,519,162 bp[2] End 54,531,730 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amygdala caudate nucleus dorsolateral prefrontal cortex prefrontal cortex nucleus accumbens hippocampus proper postcentral gyrus putamen entorhinal cortex Brodmann area 9 Top expressed in superior frontal gyrus olfactory tubercle cerebellar cortex nucleus accumbens globus pallidus subiculum cerebellar vermis piriform cortex superior colliculus primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function syntaxin-1 binding syntaxin binding SNARE binding calcium-dependent protein binding Cellular component cytoplasm cytosol synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex mast cell granule synapse synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex neuronal cell body dendrite SNARE complex presynapse calyx of Held postsynapse glutamatergic synapse terminal bouton Biological process cell differentiation synaptic vesicle exocytosis nervous system development positive regulation of synaptic plasticity vesicle docking involved in exocytosis regulation of exocytosis mast cell degranulation neurotransmitter transport exocytosis regulation of synaptic vesicle fusion to presynaptic active zone membrane regulation of neurotransmitter secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10814 12890 Ensembl ENSG00000145920 ENSMUSG00000025867 UniProt Q6PUV4 P84086 RefSeq (mRNA) NM_001008220 NM_006650 NM_032282 NM_009946 NM_001362218 RefSeq (protein) NP_001008221 NP_006641 NP_034076 NP_001349147 Location (UCSC) Chr 5: 175.8 – 175.88 Mb Chr 13: 54.52 – 54.53 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene.^[7]