Draft:Christoph Schreiner

Schreiner grew up in Zernien, Germany. His father was the local doctor. Schreiner attended the same medical school, Georg-August-Universität Göttingen. He also obtained a Doctor of Philosophy in Physics, working under Prof. Manfred R. Schroeder, who was a faculty member at the Third Institute of Physics at the Georg-August-Universität Göttingen and studied real-world acoustics problems in speech, hearing, and concert hall acoustics. Schreiner combined his interests in human physiology and acoustics to research auditory psychophysics phenomena from the perspective of the biophysics and physiology of the sensory nervous system.

In 1977, Schreiner began training in auditory physiology during his first postdoctoral position in Göttingen at the Max Planck Institute lab of Prof. Otto Creutzfeldt. Schreiner published his first auditory cortex paper on the “Thalamocortical transformation of responses to complex auditory stimuli” in 1980^[6].

After completing his training in 1980, Schreiner was sent by Creutzfeldt to do a short postdoc with Michael M. Merzenich in California to broaden his auditory neurophysiology experience before returning to lead an Auditory Group at Max Planck. What was initially just a one-year fellowship eventually became a 30 year collaboration studying the organization of sound feature representations in the cortex, as well as the mechanisms and therapeutic applications of cortical plasticity.

Schreiner spent his entire academic career in the UCSF Department of Otolaryngology-Head and Neck Surgery^[7]. He started as an Assistant Research Physiologist in 1984 and rose through the University of California academic ranks^[8] to reach Professor in Residence in 1996, and to Professor in 2007. He served as Vice-Chair of the Department from 2004-2019. He also held the position of Professor in Bioengineering & Therapeutic Sciences^[9] from 2009-2024.

Schreiner has published over 140 articles^[10].

A large part of Schreiner’s research focused on understanding how the auditory cortex in rodents, cats, and new world monkeys is organized. Electrophysiological mapping studies across various areas within the auditory cortex revealed a number of organizational principles and neuroanatomical correlates for temporal and spectral components of sounds^{[4][5][11][12][13]} superimposed on or in addition to the well-known tonotopic organization.

Along with his long-time collaborator Dr. Jeff Winer^[14], Schreiner published a reference on the Auditory Cortex in 2011^[15].

Schreiner's research demonstrated that spectral and temporal response properties and spatial organization in the inferior colliculus^[16][17] and the medial geniculate nucleus^[6][18][19] show distinct differences from cortical neurons, giving rise to a neural coding transformation as sound information ascends the auditory neuraxis.

Schreiner and Winer published a comprehensive reference on the Inferior Colliculus^[20] in 2005.

Another dimension of Schreiner's research has been to uncover the expressions and mechanisms of experience-induced representational plasticity in core auditory cortex, including for sound frequency, amplitude modulation, frequency modulation, and sound intensity^{[21][22][23][24][25]}. Specific interactions between excitatory and inhibitory inputs, modulated by release of neurotransmitters such as acetylcholine underlie rapid plastic changes of receptive fields and result in behaviorally testable changes in psychophysical performance.

Schreiner's lab expanded the computational tool set for characterizing nonlinear properties of central auditory responses. Using information-theoretic approaches and variations on the spike-triggered receptive field approach, they demonstrated that central, especially cortical, receptive fields require a more complex, multi-dimensional description to capture their processing than most midbrain or thalamic neurons^{[26][27][28][29][30]}.

Schreiner and colleagues published several studies on the effect of electrical cochlear stimulation on the evoked activity in cortical neurons in animal models and on the expression of tinnitus in implant patients^{[31][32][33][34]}.

Schreiner was funded by the National Institutes of Health for over 30 years. As a U.S. government-funded principal investigator, he reviewed NIH grants as a member of the AUD study section of the Center for Scientific Review^[35] and chaired it from 2005-2007. He served on the Advisory Council^[36] for the National Institute on Deafness and Other Communication Disorders (2016-2019) and was a member of the Multi Council Workgroup^[37] for the BRAIN Initiative.

Internationally, he has been the chair of the Scientific Advisory Board for the Cluster of Excellence "Hearing4All" program in Oldenburg, Germany^[38] since 2011. He has also served on the editorial board for Hearing Research, Experimental Brain Research, and was an Associate Editor for the Journal of the Association for Research in Otolaryngology^[39] and the journal Audiology & Neuro-Otology^[40].

Schreiner advised or co-advised 22 doctoral students, and 25 post-doctoral fellows.

While working in the Coleman Laboratory at UCSF with Michael M. Merzenich, he met cochlear implant team audiologist, Marcia Raggio. He and Raggio were married in San Francisco in 1988. He became stepfather to Marcia’s son, Noah, and their daughter Christina was born in 1991. Christina completed her clinical doctorate in psychology at the Wright Institute in Berkeley in 2023.