List of estrogen esters

Many esters of estradiol have been marketed, including the following major esters:^[1][2]

• Estradiol acetate (Femring, Femtrace, Menoring)
• Estradiol benzoate (Agofollin Depot, Progynon-B; Duogynon, Primosiston, Sistocyclin)
• Estradiol cypionate (Depo-Estradiol, Depofemin, Estradep; Cyclofem, Lunelle)
• Estradiol dipropionate (Agofollin, Di-Ovocyclin, Progynon-DP; EP Hormone Depot)
• Estradiol enantate (Perlutal, Topasel, Unalmes, Yectames)
• Estradiol undecylate (Delestrec, Progynon Depot)
• Estradiol valerate (Delestrogen, Progynon Depot, Progynova; Gravibinon, Mesigyna, Mesygest)
• Polyestradiol phosphate (Estradurin) (an estradiol ester in polymeric form)

And the following less commonly used esters:^[1][2]

• Cloxestradiol acetate (Genovul; diacetate ester of cloxestradiol, or estradiol 17β-chloral hemiacetal ether)
• Estradiol benzoate butyrate (Redimen, Soluna, Unijab, Unimens)
• Estradiol butyrylacetate (Follikoside)
• Estradiol dibutyrate (Triormon Depositum)
• Estradiol dienantate (Climacteron, Lactimex, Lactostat)
• Estradiol diundecylate (Estrolent; Trioestrine Retard)
• Estradiol diundecylenate (Etrosteron)
• Estradiol furoate (Di-Folliculine)
• Estradiol hemisuccinate (Eutocol; Hosterona)
• Estradiol hemihydrate (Estrofem)
• Estradiol hexahydrobenzoate (Benzo-Ginoestril A.P., BenzoGynoestryl Retard, Ginestryl-15-Depot, Menodin, Tardoginestryl)
• Estradiol palmitate (Esmopal)
• Estradiol phenylpropionate (Dimenformon Prolongatum; Estandron Prolongatum, Lynandron Prolongatum, Mixogen)
• Estradiol pivalate (Estrotate; Estrotate with Progesterone)
• Estradiol propionate (estradiol 17β-propionate) (Acrofollin, Akrofollin, Follhormon)
• Estradiol propoxyphenylpropionate (Durovex)
• Estradiol stearate (Depofollan)
• Estradiol sulfate (a minor constituent of conjugated estrogens (Premarin))

The following nitrogen mustard ester of estradiol is a cytostatic antineoplastic agent and has been marketed:^[1][2]

• Estramustine phosphate (Emcyt, Estracyt; estradiol 3-normustine 17β-phosphate)

A number of other estradiol esters which have not been marketed include:^[2]

• Estradiol 3-furoate^[3]
• Estradiol 3-propionate (not to be confused with estradiol monopropionate (estradiol 17β-propionate))
• Estradiol 17β-(1-(4-(aminosulfonyl)benzoyl)-L-proline) (EC508)^[4][5][6][7]
• Estradiol acetate benzoate^[8][9]
• Estradiol 17β-acetate
• Estradiol 17β-benzoate
• Estradiol acetylsalicylate (estradiol 3-acetylsalicylate)^[10][11]
• Estradiol anthranilate (estradiol 3-anthranilate)^[10][11]
• Estradiol arachidonate
• Estradiol benzoate cyclooctenyl ether (estradiol 3-benzoate 17β-cyclooctenyl ether; EBCO)^[12][13]
• Estradiol caprylate (estradiol octanoate)^[14][15]
• Estradiol cyclooctyl acetate (E2CoA)^[16]
• Estradiol decanoate (estradiol 17β-decanoate)^[17]
• Estradiol diacetate
• Estradiol dibenzoate
• Estradiol dicypionate
• Estradiol dioleate
• Estradiol dipalmitate
• Estradiol distearate
• Estradiol disulfate
• Estradiol glucuronide
• Estradiol sulfate glucuronide
• Estradiol linoleate
• Estradiol oleate
• Estradiol phosphate
• Estradiol salicylate (estradiol 3-salicylate)^[10][11]
• Estradiol sulfamate (E2MATE; J995, PGL-2, PGL-2001, ZK-190628; estradiol-3-O-sulfamate)
• Estradiol undecylenate (SH-368)
• Estrapronicate (estradiol 3-propionate 17β-nicotinate; Trophobolene, Trophoboline)
• Orestrate (estradiol 3-propionate 17β-(1-cyclohexenyl) ether)

The following cytostatic antineoplastic nitrogen mustard esters of estradiol have not been marketed:^[2]

• Alestramustine (estradiol 3-(bis(2-chloroethyl)carbamate), 17-ester with L-alanine)
• Atrimustine (KM-2210; bestrabucil, busramustine)
• Estradiol mustard (NSC-112259; chlorphenacyl estradiol diester)
• Estramustine (Leo 275; Ro 21-8837)
• Estromustine (Leo 271 f; estrone 17β-3-N-bis(2-chloroethyl)carbamate, estrone–cytostatic complex)

Esters of estrone that have been marketed include:^[1][2]

• Estrone acetate (Hovigal)
• Estrone sulfate (as the primary component of conjugated estrogens (Premarin))
  • Estropipate (Ogen, Ortho-Est) (a salt of estrone sulfate and piperazine)
• Estrone tetraacetylglucoside (Glucovex, Glycovex)

Other estrone esters which are notable but have not been marketed include:

• Estrone benzoate
• Estrone cyanate
• Estrone enanthate^[18]
• Estrone enanthate benzilic acid hydrazone^[18]
• Estrone glucuronide
• Estrone phosphate
• Estrone propionate^[19]
• Estrone sulfamate (EMATE; J994; estrone-3-O-sulfamate)
• Estrone oleate

Esters of estriol that have been marketed include:^[1][2]

• Estriol 3-glucuronide (as a component of conjugated estriol (Emmenin, Progynon))
• Estriol acetate benzoate (Holin-Depot)
• Estriol glucuronide (as a component of conjugated estriol (Emmenin, Progynon))
• Estriol succinate (Sinapause, Styptanon, Synapause)
  • Estriol sodium succinate (Pausan, Styptanon)
• Estriol sulfate (as a component of conjugated estriol (Emmenin, Progynon))
• Estriol sulfate glucuronide (as a component of conjugated estriol (Emmenin, Progynon))
• Estriol tripropionate (Estriel)
• Polyestriol phosphate (Gynäsan, Klimadurin, Triodurin) (an estriol ester in polymeric form)

The following ester of estriol was never marketed:

• Estriol dihexanoate
• Estriol dipropionate
• Estriol phosphate (E3P)
• Estriol sulfamate (E3MATE; J1034; estriol-3-O-sulfamate)
• Estriol triacetate

The following esters of ethinylestradiol exist and have been marketed:^[1][2]

• Ethinylestradiol sulfonate (Turisteron; ethinylestradiol 3-isopropylsulfonate)

• Ethinylestradiol benzoate – the 3-benzoate ester of ethinylestradiol
• Ethinylestradiol N,N-diethylsulfamate (J271) – the 3-(N,N-diethyl)sulfamate ester of ethinylestradiol^[20]
• Ethinylestradiol pyrrolidinosulfonate (J272) – the 3-pyrrolidinosulfonate ester of ethinylestradiol^[20]
• Ethinylestradiol sulfamate (J1028) – the 3-sulfamate ester of ethinylestradiol^[21]
• Ethinylestradiol sulfate

The following esters of other estrogens exist and have been marketed:^[1]

• Hydroxyestrone diacetate (Colpoginon, Colpormon, Hormobion, Hormocervix) – the 3,16α-diacetate ester of 16α-hydroxyestrone

A number of estrogen ethers also exist and have been marketed, including:^[22][1]

• Clomestrone (Arterolo, Atheran, Colesterel, Iposclerone, Liprotene, Persclerol) – the 3-methyl ether of 16α-chloroestrone
• Cloxestradiol acetate (Genovul) – the O,O-diacetate ester of cloxestradiol (estradiol 17β-chloral hemiacetal ether)
• Mestranol (Devocin, Ovastol, Tranel) (component of Enovid, Enavid, Ortho-Novin, Femigen, Norbiogest) – the 3-methyl ether of ethinylestradiol
• Moxestrol (Surestryl) – the 11β-methoxy derivative of ethinylestradiol (and hence the 11β-methyl ether of the 11β-hydroxyl derivative of ethinylestradiol)
• Nilestriol (Wei Ni An) – the 3-cyclopentyl ether of ethinylestriol
• Promestriene (Colpotrofin, Colpotrophine, Delipoderm) – the 3-propyl and 17β-methyl diether of estradiol
• Quinestradol (Colpovis, Colpovister, Pentovis) – the 3-cyclopentyl ether of estriol
• Quinestrol (Agalacto-Quilea, Basaquines, Eston, Estrovis, Estrovister, Plestrovis, Qui-lea) – the 3-cyclopentyl ether of ethinylestradiol

A few other estrogen ethers which are notable but have not been marketed include:^[22]

• Cloxestradiol – the 17β-chloral hemiacetal ether of estradiol
• Estradiol benzoate cyclooctenyl ether – the 17β-cyclooctenyl ether of estradiol 3-benzoate^[12]
• Estradiol 3-saccharinylmethyl ether – the 3-(saccharinylmethyl) ether of estradiol^[23][24]
• Estradiol 3-tetrahydropyranyl ether – the 3-(tetrahydropyran-2-yl) ether of estradiol^[25]
• Estradiol 17β-tetrahydropyranyl ether – the 17β-(tetrahydropyran-2-yl) ether of estradiol^[25]
• Estrone methyl ether – the 3-methyl ether of estrone
• Mytatrienediol – the 3-methyl ether of 16α-methyl-16β-epiestriol
• Orestrate – the 17β-(1-cyclohexenyl) ether of estradiol 3-propionate

Major esters of diethylstilbestrol include:

• Diethylstilbestrol dipropionate (Agostilben, Biokeral, Clinestrol, Cyclen, Estilbin, Estril, Neobenzoestrol, Orestol, Oroestrol, Ostregenin, Prostilbene, Stilbestriol DP, Stilboestrolum Dipropionicum, Stilboestrol, Synestrin, Willestrol)
• Fosfestrol (diethylstilbestrol diphosphate) (Honvan, Difostilben, Fosfostilben, Fostrolin, Stilbol, Stilphostrol, Vagestrol)

Less commonly used esters of diethylstilbestrol include:

• Diethylstilbestrol diacetate (Hormostilboral Stark)
• Diethylstilbestrol dilaurate (Acnestrol-Lotion)
• Diethylstilbestrol dipalmitate (stilpalmitate) (Palmestril, Stilpalmitate)
• Diethylstilbestrol disulfate (Hydroestryl, Idroestril)

• Diethylstilbestrol sulfate
• Furostilbestrol (diethylstilbestrol difuroate)
• Polydiethylstilbestrol phosphate

As well as the following nitrogen mustard ester:

• ICI-85966 (Stilbostat; diethylstilbestrol bis(di(2-chloroethyl)carbamate))

• Hexestrol diacetate (Retalon Lingual, Robal, Sintestrol, Sintofolin)
• Hexestrol dicaprylate (dioctanoylhexestrol) (Taston)
• Hexestrol diphosphate (Cytostesin, Pharmestrin, Retalon Aquosum)
• Hexestrol dipropionate (Hexanoestrol, Retalon Oleosum)
• Hexestrol phosphate (Retalon Aquosum)

The following nitrogen mustard ester of hexestrol was never marketed:

• Phenestrol (fenestrol; hexestrol bis[4-[bis(2-chloroethyl)amino]phenylacetate)

• Dienestrol diacetate (Faragynol, Gynocyrol)
• Methestrol dipropionate (promethestrol dipropionate, dimethylhexestrol dipropionate) (Meprane Dipropionate)

• Diethylstilbestrol monobenzyl ether (benzelstilbestrol) (Monozol, Hypantin, Pituitrope)
• Dimestrol (dianisylhexene, diethylstilbestrol dimethyl ether, dimethoxydiethylstilbestrol) (Depot-Ostromon, Synthila)
• Mestilbol (diethylstilbestrol monomethyl ether) (Monomestro or Monomestrol)

• List of estrogens
• List of progestogen esters
• List of androgen esters
• List of combined sex-hormonal preparations