FAM105B

Family with sequence similarity 105, member B is a protein in humans that is encoded by the FAM105B gene.^[5]

OTULIN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3ZNV, 3ZNX, 3ZNZ, 4KSJ, 4KSK, 4KSL, 4OYK, 4P0B
Identifiers
Aliases	OTULIN, FAM105B, GUM, OTU deubiquitinase with linear linkage specificity, AIPDS
External IDs	OMIM: 615712; MGI: 3577015; HomoloGene: 106591; GeneCards: OTULIN; OMA:OTULIN - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p15.2 Start 14,664,664 bp[1] End 14,699,850 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B1 Start 27,542,721 bp[2] End 27,630,779 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells pancreatic ductal cell sural nerve monocyte Achilles tendon thymus skin of abdomen blood tibialis anterior muscle lymph node Top expressed in yolk sac left lobe of liver saccule spermatid soleus muscle proximal tubule otic placode spleen lip primitive streak More reference expression data BioGPS n/a
Gene ontology Molecular function cysteine-type peptidase activity thiol-dependent deubiquitinase peptidase activity protein binding hydrolase activity Cellular component cytosol LUBAC complex cytoplasm Biological process immune system process Wnt signaling pathway proteolysis nucleotide-binding oligomerization domain containing 2 signaling pathway angiogenesis canonical Wnt signaling pathway sprouting angiogenesis protein linear deubiquitination regulation of tumor necrosis factor-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity innate immune response negative regulation of inflammatory response regulation of canonical Wnt signaling pathway protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 90268 432940 Ensembl ENSG00000154124 ENSMUSG00000046034 UniProt Q96BN8 Q3UCV8 RefSeq (mRNA) NM_138348 NM_001013792 RefSeq (protein) NP_612357 NP_001013814 Location (UCSC) Chr 5: 14.66 – 14.7 Mb Chr 15: 27.54 – 27.63 Mb PubMed search [3] [4]
Wikidata
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