FGF7

FGF7
Identifiers
Aliases	FGF7, HBGF-7, KGF, fibroblast growth factor 7
External IDs	OMIM: 148180; MGI: 95521; HomoloGene: 7316; GeneCards: FGF7; OMA:FGF7 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	49,488,775 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	125,933,105 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; stromal cell of endometrium; ; gallbladder; ; tibial nerve; ; canal of the cervix; ; left uterine tube; ; sural nerve; ; right lobe of thyroid gland; ; right lung; ; subcutaneous adipose tissue;
	Top expressed in
	calvaria; ; cerebellar vermis; ; intercostal muscle; ; left lung lobe; ; ankle; ; detrusor urinae muscle; ; right lung; ; digastric muscle; ; fossa; ; carotid body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heparin binding; fibroblast growth factor receptor binding; protein binding; chemoattractant activity; growth factor activity; 1-phosphatidylinositol-3-kinase activity; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Cellular component	Golgi apparatus; extracellular region;
Biological process	actin cytoskeleton reorganization; mesenchymal cell proliferation; positive regulation of keratinocyte proliferation; positive regulation of epithelial cell proliferation involved in lung morphogenesis; secretion by lung epithelial cell involved in lung growth; positive regulation of epithelial cell proliferation; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; MAPK cascade; positive regulation of transcription, DNA-templated; fibroblast growth factor receptor signaling pathway; positive regulation of keratinocyte migration; protein localization to cell surface; response to wounding; positive regulation of cell population proliferation; epidermis development; positive regulation of peptidyl-tyrosine phosphorylation; hair follicle morphogenesis; positive chemotaxis; positive regulation of cell division; signal transduction; branching involved in salivary gland morphogenesis; phosphatidylinositol phosphate biosynthetic process; peptidyl-tyrosine phosphorylation; phosphatidylinositol-3-phosphate biosynthetic process; regulation of signaling receptor activity; positive regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	2252
	14178
	ENSG00000140285
	ENSMUSG00000027208
	P21781
	P36363
	NM_002009
	NM_008008
	NP_002000
	NP_032034
	Wikidata
View/Edit Human	View/Edit Mouse

Keratinocyte growth factor is a protein that in humans is encoded by the FGF7 gene.^[5]^[6]^[7]

Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.^[7]

Interactions

FGF7 has been shown to interact with Perlecan.^[8]

Search

FGF7

Contents

Function

Interactions

References

Further reading