Folin's reagent or sodium 1,2-naphthoquinone-4-sulfonate is a chemical reagent used as a derivatizing agent to measure levels of amines and amino acids.[1] The reagent reacts with them in alkaline solution to produce a fluorescent material that can be easily detected.[2]
Names | |
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Preferred IUPAC name Sodium 3,4-dioxo-3,4-dihydronaphthalene-1-sulfonate | |
Identifiers | |
3D model (JSmol) | |
ChemSpider | |
ECHA InfoCard | 100.007.555 |
EC Number |
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PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
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Properties | |
C10H5NaO5S | |
Molar mass | 260.20 g/mol |
Hazards | |
Safety data sheet (SDS) | Oxford MSDS |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
This should not be confused with Folin-Ciocalteu reagent, that is used to detect phenolic compounds.
The Folin reagent can be used with an acidic secondary reagent to distinguish MDMA and related compounds from PMMA and related compounds.[3][failed verification]
Substance | Reaction |
---|---|
MDMA | Pink[3] |
MDE | No Reaction[3] |
MDA | Yellow[3] |
BZP | Orange to red[3] |
TFMPP | Pinkish red[3] |
Methylone | No reaction[3] |
Methamphetamine | Pink[3] |
Amphetamine | Light orange[3] |
PMA | Light Yellow[3] |
PMMA | Light orange[3] |
Ketamine | No reaction[3] |
Mescaline | No reaction[3] |
Cocaine | No reaction[3] |
Aspirin | No reaction[3] |
Sugar | No reaction[3] |
See also
References
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