HBE1

HBE1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A9W
Identifiers
Aliases	HBE1, HBE, hemoglobin subunit epsilon 1
External IDs	OMIM: 142100; MGI: 96024; HomoloGene: 110794; GeneCards: HBE1; OMA:HBE1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	5,505,652 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	103,492,371 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; ganglionic eminence; ; blood; ; monocyte; ; stromal cell of endometrium; ; apex of heart; ; ventricular zone; ; gastrocnemius muscle; ; anterior cingulate cortex;
	Top expressed in
	abdominal wall; ; yolk sac; ; somite; ; endocardial cushion; ; internal carotid artery; ; maxillary prominence; ; external carotid artery; ; hand; ; mandibular prominence; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	hemoglobin alpha binding; metal ion binding; heme binding; iron ion binding; oxygen binding; oxygen carrier activity; protein binding; peroxidase activity; haptoglobin binding; organic acid binding;
Cellular component	cytosol; blood microparticle; hemoglobin complex; haptoglobin-hemoglobin complex;
Biological process	protein heterooligomerization; blood coagulation; oxygen transport; response to organic cyclic compound; transport; hydrogen peroxide catabolic process; cellular oxidant detoxification;
	Sources:Amigo / QuickGO
Orthologs
	3046
	15132
	ENSG00000213931
	ENSMUSG00000052217
	P02100
	P04444
	NM_005330
	NM_008219
	NP_005321; NP_005321.1
	NP_032245
	Wikidata
View/Edit Human	View/Edit Mouse

Hemoglobin subunit epsilon is a protein that in humans is encoded by the HBE1 gene.^[5]

Function

The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.^[6]

Search

HBE1

Contents

Function

See also

References

Further reading