IL36A

Interleukin-36 alpha also known as interleukin-1 family member 6 (IL1F6) is a protein that in humans is encoded by the IL36A gene.^[5][6]

IL36A
Identifiers
Aliases	IL36A, FIL1, FIL1(EPSILON), FIL1E, IL-1F6, IL1(EPSILON), IL1F6, interleukin 36, alpha, interleukin 36 alpha
External IDs	OMIM: 605509; MGI: 1859324; HomoloGene: 8688; GeneCards: IL36A; OMA:IL36A - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.1 Start 113,005,459 bp[1] End 113,008,044 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A3|2 16.26 cM Start 24,105,430 bp[2] End 24,115,714 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of esophagus testicle oral cavity mucosa of pharynx body of tongue pancreatic ductal cell buccal mucosa cell gums tonsil vagina Top expressed in esophagus lip cervix right ventricle skin of external ear belly cord tibiofemoral joint lumbar subsegment of spinal cord temporal muscle digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-1 receptor binding cytokine activity Cellular component extracellular region extracellular space Biological process positive regulation of interleukin-6 production innate immune response positive regulation of cytokine production immune system process inflammatory response immune response regulation of signaling receptor activity cytokine-mediated signaling pathway neutrophil chemotaxis positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JNK cascade cellular response to lipopolysaccharide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27179 54448 Ensembl ENSG00000136694 ENSMUSG00000026984 UniProt Q9UHA7 Q9JLA2 RefSeq (mRNA) NM_014440 NM_019450 RefSeq (protein) NP_055255 NP_062323 Location (UCSC) Chr 2: 113.01 – 113.01 Mb Chr 2: 24.11 – 24.12 Mb PubMed search [3] [4]
Wikidata
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