Isoconazole

Isoconazole
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	D01AC05 (WHO) G01AF07 (WHO);
Identifiers
	IUPAC name (RS)-1-[2-[(2,6-Dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole;
CAS Number	27523-40-6;
PubChem CID	3760;
DrugBank	DB08943 ;
ChemSpider	3629;
UNII	GRI7WFR424;
KEGG	D04624;
ChEBI	CHEBI:82865 ;
ChEMBL	ChEMBL1571863;
CompTox Dashboard (EPA)	DTXSID7045447 ;
ECHA InfoCard	100.044.084
Chemical and physical data
Formula	C18H14Cl4N2O
Molar mass	416.12 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc(c(Cl)c1)C(OCc2c(Cl)cccc2Cl)Cn3ccnc3;

Isoconazole is an azole antifungal drug and could inhibit gram positive bacteria.^[1]^[2] For foot and vaginal infections, isoconazole has a similar effectiveness to clotrimazole.^[3]^[4] Isoconazole nitrate may be used in combination with corticosteroid diflucortolone to increase its bioavailability.^[1]

It was patented in 1968 and approved for medical use in 1979.^[5]

References