Japan National Route 221

National Route 221 is a national highway of Japan connecting Hitoyoshi and Miyakonojō in Japan, with a total length of 74.6 km (46.4 mi).

National Route 221
国道221号
Route information
Length	74.6 km[1] (46.4 mi)
Existed	18 May 1953–present
Major junctions
North end	National Route 219 in Hitoyoshi
South end	National Route 10 in Miyakonojō
Location
Country	Japan
Highway system
National highways of Japan Expressways of Japan
← National Route 220 → National Route 222