LPAR3

LPAR3
Identifiers
Aliases	LPAR3, EDG7, Edg-7, GPCR, HOFNH30, LP-A3, LPA3, RP4-678I3, lysophosphatidic acid receptor 3
External IDs	OMIM: 605106; MGI: 1929469; HomoloGene: 8123; GeneCards: LPAR3; OMA:LPAR3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	84,893,206 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	145,991,941 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; right uterine tube; ; mucosa of paranasal sinus; ; spinal ganglia; ; olfactory zone of nasal mucosa; ; trigeminal ganglion; ; atrium; ; right auricle; ; myocardium; ; cardiac muscle tissue of right atrium;
	Top expressed in
	lumbar spinal ganglion; ; endocardial cushion; ; right kidney; ; membranous bone; ; Dermatocranium; ; maxilla; ; mandible; ; vestibular membrane of cochlear duct; ; atrioventricular junction; ; atrioventricular valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; lysophosphatidic acid receptor activity; G-protein alpha-subunit binding; phospholipid binding; lipid binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; axon; plasma membrane;
Biological process	chemical synaptic transmission; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of cytosolic calcium ion concentration; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; bleb assembly; positive regulation of collateral sprouting; signal transduction; positive regulation of MAPK cascade; positive regulation of calcium ion transport; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23566
	65086
	ENSG00000171517
	ENSMUSG00000036832
	Q9UBY5
	Q9EQ31
	NM_012152
	NM_022983
	NP_036284
	NP_075359
	Wikidata
View/Edit Human	View/Edit Mouse

Lysophosphatidic acid receptor 3 also known as LPA₃ is a protein that in humans is encoded by the LPAR3 gene.^[5]^[6] LPA₃ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).^[7]

Function

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.^[5]

Evolution

Paralogues^[8]

References

External links

"Lysophospholipid Receptors: LPA₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-05.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[5]

[6]

[7]

[1]

[2]

[3]

[4]

[8]

Search

LPAR3

Contents

Function

Evolution

Paralogues^[8]

See also

References

Further reading

External links

LPAR3

Function

Evolution

Paralogues[8]

See also

References

Further reading

External links

Paralogues^[8]