Latrophilins are a group of highly conserved G-protein coupled receptors from the adhesion G protein-coupled receptor family. These receptors were originally identified based on their ability to bind to a component of black widow spider venom known as alpha-latrotoxin.[1] This conserved family of membrane proteins has up to three homologues in chordate species, including humans.[2]
| Latrophilin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Latrophilin | ||||||||
| Pfam | PF02354 | ||||||||
| InterPro | IPR003334 | ||||||||
| |||||||||
| EGF, latrophilin and seven transmembrane domain containing 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ELTD1 | ||||||
| Alt. symbols | ETL | ||||||
| NCBI gene | 64123 | ||||||
| HGNC | 20822 | ||||||
| RefSeq | NM_022159 | ||||||
| UniProt | Q9HBW9 | ||||||
| Other data | |||||||
| Locus | Chr. 1 p33-p32 | ||||||
| |||||||
| latrophilin 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | LPHN1 | ||||||
| Alt. symbols | KIAA0821, CIRL1, LEC2 | ||||||
| NCBI gene | 22859 | ||||||
| HGNC | 20973 | ||||||
| RefSeq | NM_014921 | ||||||
| UniProt | O94910 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13.2 | ||||||
| |||||||
| latrophilin 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | LPHN2 | ||||||
| Alt. symbols | LPHH1, KIAA0786, LEC1 | ||||||
| NCBI gene | 23266 | ||||||
| HGNC | 18582 | ||||||
| OMIM | 607018 | ||||||
| RefSeq | NM_012302 | ||||||
| UniProt | O95490 | ||||||
| Other data | |||||||
| Locus | Chr. 1 p31.1 | ||||||
| |||||||
| latrophilin 3 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | LPHN3 | ||||||
| Alt. symbols | KIAA0768, LEC3 | ||||||
| NCBI gene | 23284 | ||||||
| HGNC | 20974 | ||||||
| RefSeq | NM_015236 | ||||||
| UniProt | Q9HAR2 | ||||||
| Other data | |||||||
| Locus | Chr. 4 q13.1 | ||||||
| |||||||
The precise functions of latrophilins remain unknown.[2] Genetic defects in latrophilin genes have been associated with diseases such as attention-deficit hyperactivity disorder and cancer.[3]
Human proteins containing this domain
See also
References
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