List of tallest buildings in Winston-Salem

Below is a list of the 10 tallest buildings in Winston-Salem above 200 feet. The tallest building in Winston-Salem, North Carolina is 100 North Main Street. The 2nd tallest building in Winston-Salem the tallest in Winston-Salem from 1966 to 1995 and the tallest building in North Carolina from 1966 to 1971 when Two Wells Fargo Center in Charlotte was constructed.

Tallest buildings

Rank	Name	Image	Height ft / m	Floors	Year	Notes
1	100 North Main Street		460 / 140^[1]	34	1995	Tallest building in Winston-Salem since 1995, as well as the tallest in North Carolina outside of Charlotte and Raleigh The building contains 549,000 square feet (51,000 m²) of space. It was 95% leased as February 2012, tenants at that time included Wells Fargo, Deutsche Bank Securities, Morgan Stanley Smith Barney and Wake Forest Baptist Medical Center.^[2] In October 2018 WFC Property LLC of Oklahoma City purchased the building for $62 million.^[3]
2	Winston Tower		410 / 125^[4]	30	1966	Tallest building in Winston-Salem from 1966 to 1995. Tallest building in Winston-Salem constructed in the 1960s.
3	GMAC Tower		330 / 110.6^[5]	21	1980
4	Reynolds Building		314 / 95.7^[6]	22	1929	Tallest building in Winston-Salem from 1929 to 1966.
5	BB&T Financial Center		273 / 83.2^[7]	21	1987	Office building.
6	RJR Plaza Building		269 / 82^[8]	12	1929
7	Nissen Building		246 / 75^[9]	20	1927	Tallest building in Winston-Salem from 1927 to 1929.
8	Marriott Winston Plaza Hotel		237 / 72.2^[10]	19	1984	Tallest full-service hotel in Winston Salem
9	Liberty Plaza	Upload image	230 / 70.1^[11]	14	1973
10	Janeway Clinical Sciences Tower	Upload image	225 / 68.6^[12]	12	1989
11	One West Fourth Street	Upload image	211 / 64.3^[13]	13	2002


Name	Height ft (m)	Floors	Years tallest
Nissen Building	246 / 75^[9]	20	1927-1929
Reynolds Building	314 / 95.7^[6]	22	1929-1966
Winston Tower	410 / 125^[4]	30	1966-1995
100 North Main Street	460 / 140^[1]	34	1995–present