MP2 or MP-2 may refer to:
Aviation
- The second terminal of Marseille Provence Airport
- Chyetverikov ARK-3 flying-boat
Firearms
Science
- MP 2, an abbreviation for a zone during the Paleocene
- Møller–Plesset perturbation theory of the second order, a method in the field of computational chemistry
Technology
File formats
- MPEG-1 Audio Layer II audio compression format and .mp2 file format
- MPEG-2 video format
Video games
- Mario Party 2, a 1999 party game for the Nintendo 64 and the second game for the console
- Max Payne 2: The Fall of Max Payne, a 2003 shooter game
- Metroid Prime 2: Echoes, a 2004 action-adventure game