NRXN2

Neurexin-2-alpha is a protein that in humans is encoded by the NRXN2 gene.^[5][6]

NRXN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NXR
Identifiers
Aliases	NRXN2, neurexin 2
External IDs	OMIM: 600566; MGI: 1096362; HomoloGene: 86984; GeneCards: NRXN2; OMA:NRXN2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 64,606,174 bp[1] End 64,723,197 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 Start 6,468,761 bp[2] End 6,594,199 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum prefrontal cortex right frontal lobe amygdala cingulate gyrus anterior cingulate cortex Brodmann area 9 ganglionic eminence paraflocculus of cerebellum cerebellar vermis Top expressed in cerebellum cerebellar cortex olfactory bulb primary visual cortex superior frontal gyrus hypothalamus striatum of neuraxis dentate gyrus of hippocampal formation granule cell hippocampus proper layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuroligin family protein binding transmembrane signaling receptor activity cell adhesion molecule binding calcium channel regulator activity metal ion binding Cellular component integral component of membrane membrane plasma membrane presynapse protein-containing complex Biological process neuron cell-cell adhesion cell adhesion signal transduction gephyrin clustering involved in postsynaptic density assembly postsynaptic density protein 95 clustering vocalization behavior vocal learning neuroligin clustering involved in postsynaptic membrane assembly adult behavior postsynaptic membrane assembly social behavior synapse assembly neurotransmitter secretion chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9379 18190 Ensembl ENSG00000110076 ENSMUSG00000033768 UniProt P58401 Q9P2S2 E9Q7X7 RefSeq (mRNA) NM_015080 NM_138732 NM_138734 NM_001376262 NM_001376263 NM_001376265 NM_001376266 NM_001376267 NM_001400681 NM_001400682 NM_001205234 NM_001205235 NM_020253 NM_001369363 RefSeq (protein) NP_055895 NP_620060 NP_620063 NP_001363191 NP_001363192 NP_001363194 NP_001363195 NP_001363196 NP_055895.1 NP_620060.1 NP_001192163 NP_001192164 NP_064649 NP_001356292 Location (UCSC) Chr 11: 64.61 – 64.72 Mb Chr 19: 6.47 – 6.59 Mb PubMed search [3] [4]
Wikidata
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Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins.^[6]