NUAK2

NUAK family SNF1-like kinase 2 also known as SNF1/AMP kinase-related kinase (SNARK) is an enzyme that in humans is encoded by the NUAK2 gene.^[5][6] Its deficiency in humans causes anencephaly, a severe form of anterior neural tube defect that curtails brain development.^[7]

NUAK2
Identifiers
Aliases	NUAK2, SNARK, NUAK family kinase 2, ANPH2
External IDs	OMIM: 608131; MGI: 1921387; HomoloGene: 12539; GeneCards: NUAK2; OMA:NUAK2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 205,302,063 bp[1] End 205,321,745 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 132,243,864 bp[2] End 132,261,226 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood epithelium of esophagus palpebral conjunctiva renal medulla kidney tubule metanephric glomerulus jejunal mucosa oral cavity vagina kidney Top expressed in jejunum proximal tubule kidney ileum colon duodenum left colon spleen blood lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding protein kinase activity metal ion binding kinase activity transferase activity protein serine/threonine kinase activity ATP binding magnesium ion binding Cellular component cytoplasm nucleus Biological process phosphorylation apoptotic process actin cytoskeleton organization negative regulation of apoptotic process intracellular signal transduction protein phosphorylation cellular response to glucose starvation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81788 74137 Ensembl ENSG00000163545 ENSMUSG00000009772 UniProt Q9H093 Q8BZN4 RefSeq (mRNA) NM_030952 NM_001195025 NM_028778 RefSeq (protein) NP_112214 NP_001181954 NP_083054 Location (UCSC) Chr 1: 205.3 – 205.32 Mb Chr 1: 132.24 – 132.26 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse