PAFAH2

PAFAH2
Identifiers
Aliases	PAFAH2, HSD-PLA2, platelet activating factor acetylhydrolase 2
External IDs	OMIM: 602344; MGI: 2140321; HomoloGene: 37309; GeneCards: PAFAH2; OMA:PAFAH2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	25,998,117 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	134,154,724 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; islet of Langerhans; ; rectum; ; thymus; ; gastrocnemius muscle; ; gallbladder; ; stromal cell of endometrium; ; bone marrow cells; ; right lobe of liver; ; duodenum;
	Top expressed in
	left lobe of liver; ; epithelium of stomach; ; kidney; ; lacrimal gland; ; proximal tubule; ; Paneth cell; ; spermatocyte; ; pyloric antrum; ; ileum; ; left colon;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phospholipid binding; hydrolase activity; 1-alkyl-2-acetylglycerophosphocholine esterase activity;
Cellular component	cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; membrane;
Biological process	lipid catabolic process; negative regulation of apoptotic process; lipid metabolism; blood coagulation;
	Sources:Amigo / QuickGO
Orthologs
	5051
	100163
	ENSG00000158006
	ENSMUSG00000037366
	Q99487; Q5SY00
	Q8VDG7
	NM_000437
	NM_001285872; NM_001285874; NM_001285875; NM_001285877; NM_133880
	NP_000428
	NP_001272801; NP_001272803; NP_001272804; NP_001272806; NP_598641
	Wikidata
View/Edit Human	View/Edit Mouse

Platelet-activating factor acetylhydrolase 2, cytoplasmic is an enzyme that in humans is encoded by the PAFAH2 gene.^[5]^[6]^[7] It is one of several PAF acetylhydrolases.

Function

This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme.^[7]

Search

PAFAH2

Function

References

Further reading