PCDHA6

Protocadherin alpha-6 is a protein that in humans is encoded by the PCDHA6 gene.^[5][6][7]

PCDHA6
Identifiers
Aliases	PCDHA6, CNR2, CNRN2, CNRS2, CRNR2, PCDH-ALPHA6, protocadherin alpha 6
External IDs	OMIM: 606312; MGI: 1298367; HomoloGene: 75098; GeneCards: PCDHA6; OMA:PCDHA6 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 140,827,958 bp[1] End 141,012,347 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B2- B3 Start 37,100,684 bp[2] End 37,320,710 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle islet of Langerhans prefrontal cortex ganglionic eminence cerebellar cortex cerebellar hemisphere Brodmann area 9 right hemisphere of cerebellum C1 segment ventricular zone Top expressed in embryo granular layer granular layer of dentate gyrus Purkinje cell dentate gyrus of hippocampal formation granule cell Region I of hippocampus proper striatum of neuraxis hippocampus proper CA3 field neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding Cellular component integral component of membrane extracellular region plasma membrane integral component of plasma membrane membrane Biological process cell adhesion nervous system development homophilic cell adhesion via plasma membrane adhesion molecules cell-cell signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56142 12937 Ensembl ENSG00000081842 ENSMUSG00000103707 UniProt Q9UN73 n/a RefSeq (mRNA) NM_031849 NM_018909 NM_031848 NM_007767 RefSeq (protein) NP_061732 NP_114036 NP_114037 n/a Location (UCSC) Chr 5: 140.83 – 141.01 Mb Chr 18: 37.1 – 37.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.^[7]