PELO

Protein pelota homolog is a protein that in humans is encoded by the PELO gene.^[5][6]

PELO
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X52
Identifiers
Aliases	PELO, PRO1770, CGI-17, pelota homolog (Drosophila), pelota mRNA surveillance and ribosome rescue factor
External IDs	OMIM: 605757; MGI: 2145154; HomoloGene: 6835; GeneCards: PELO; OMA:PELO - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q11.2 Start 52,787,916 bp[1] End 52,804,044 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D2.2 Start 115,224,891 bp[2] End 115,226,722 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava saphenous vein left adrenal gland stromal cell of endometrium oocyte popliteal artery left coronary artery right coronary artery islet of Langerhans thoracic aorta Top expressed in urethra bone marrow vagina yolk sac epithelium of urethra placenta ejaculatory duct urinary bladder prostate kidney More reference expression data BioGPS n/a
Gene ontology Molecular function endonuclease activity nuclease activity hydrolase activity metal ion binding protein binding ribosome binding Cellular component nucleus cytoplasm Biological process cell cycle RNA surveillance cell population proliferation nuclear-transcribed mRNA catabolic process, non-stop decay chromosome organization nucleic acid phosphodiester bond hydrolysis cell division protein biosynthesis endoderm development stem cell population maintenance positive regulation of BMP signaling pathway ribosome disassembly mesenchymal to epithelial transition nonfunctional rRNA decay nuclear-transcribed mRNA catabolic process, no-go decay inner cell mass cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53918 105083 Ensembl ENSG00000152684 ENSMUSG00000042275 UniProt Q9BRX2 Q80X73 RefSeq (mRNA) NM_015946 NM_134058 RefSeq (protein) NP_057030 NP_598819 Location (UCSC) Chr 5: 52.79 – 52.8 Mb Chr 13: 115.22 – 115.23 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division.^[6] In yeasts, the Dom34-Hbs1 complex (with ABCE1) that it forms is responsible for reactivating ribosomes and for recovering those stuck on mRNAs.^[7] It is a paralog of the release factor eRF1.

The Drosophila homolog was first discovered in 1993. Mutants exhibit G2/M arrest in meiosis and large nebenkern form in late spermatocytes.^[8] Human, yeast (Dom34), plant, and worm homologs are reported in 1995,^[9] followed by one found in archaea.^[10]